LMCD1 and PRKAG3

Number of citations of the paper that reports this interaction (PMID 19616115)
4

Data Source:
BioGRID (two hybrid)

		LMCD1	PRKAG3
Gene Name		LIM and cysteine-rich domains 1	protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Extracellular Matrix	Extracellular Space Cytosol AMP-activated Protein Kinase Complex
	Molecular Function	Transcription Corepressor Activity Zinc Ion Binding	AMP-activated Protein Kinase Activity ATP Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Calcineurin-NFAT Signaling Cascade	Glycogen Biosynthetic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Insulin Receptor Signaling Pathway Glucose Transport Intracellular Signal Transduction Membrane Organization
Pathways			Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: APP FBXO25 IKBKG NKX3-1 PRKAG3 TRIM55 TRIM63	7 interactors: BRCA1 CRYAB LMCD1 NGRN PRKAA1 PRKAB1 PRKAB2
Entrez ID		29995	53632
HPRD ID		06891	16085
Ensembl ID		ENSG00000071282	ENSG00000115592
Uniprot IDs		B4DEY6 B4DG80 B7Z6R5 F5GX84 Q9NZU5	B4DUK8 Q9UGI9
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Hormone Stimulus Positive Regulation Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Positive Regulation Of Androgen Secretion Signal Transduction Cell Cycle Arrest Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Estrogen Receptor Binding Regulation Of Protein Kinase Activity Signaling Cell Communication Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Kinase Activity Cellular Response To Steroid Hormone Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Skeletal Muscle Atrophy Regulation Of Cell Cycle Axon Choice Point Recognition Striated Muscle Atrophy Response To Hormone Apoptotic Process Negative Regulation Of Receptor Binding Muscle Atrophy Programmed Cell Death Regulation Of Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Cell Death Death Neuron Remodeling Skeletal Muscle Adaptation Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Response To Abiotic Stimulus Dorsal Aorta Development Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Arrest	Fatty Acid Biosynthetic Process Fatty Acid Metabolic Process Response To Hormone Negative Regulation Of Cell Cycle Cellular Response To Organonitrogen Compound Regulation Of Lipid Biosynthetic Process Response To Ionizing Radiation Cell Cycle Arrest Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Fatty Acid Biosynthetic Process Response To Organonitrogen Compound Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Insulin Regulation Of Lipid Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Lipid Metabolic Process Response To Gamma Radiation Carboxylic Acid Metabolic Process Cell Cycle Process Regulation Of Protein Metabolic Process Organic Acid Metabolic Process Protein Oligomerization Response To Radiation Negative Regulation Of Lipid Metabolic Process Response To Peptide Hormone Response To Organic Substance Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Response To Peptide Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cell Cycle Cellular Response To Hormone Stimulus Response To Hydrogen Peroxide Positive Regulation Of Histone H3-K9 Acetylation Protein Heterooligomerization Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation
Tagcloud ?		anf antihypertrophic blunted calcineurin cardiomyocyte cardiomyocytes cardiomyopathic causal constitutionally contractile crossed disc dyxin exacerbated hypertrophic hypertrophy likewise lim mechanistically nrcm nrcms pe phenylephrine potently rcan1 sarcomeric stretch stretched upregulated	accompanying adjust alga0035896 asga0009814 asga0070634 beadchip bonferroni color consumers corresponds deregressed finnish ham illumina lightness loin meat megabases polygenic porcinesnp60 qlt rcn1 redness relatedness smallest snp substitutions traits yorkshire
Tagcloud (Difference) ?		anf antihypertrophic blunted calcineurin cardiomyocyte cardiomyocytes cardiomyopathic causal constitutionally contractile crossed disc dyxin exacerbated hypertrophic hypertrophy likewise lim mechanistically nrcm nrcms pe phenylephrine potently rcan1 sarcomeric stretch stretched upregulated	accompanying adjust alga0035896 asga0009814 asga0070634 beadchip bonferroni color consumers corresponds deregressed finnish ham illumina lightness loin meat megabases polygenic porcinesnp60 qlt rcn1 redness relatedness smallest snp substitutions traits yorkshire
Tagcloud (Intersection) ?