MLH3 and MLH1

Number of citations of the paper that reports this interaction (PMID 10615123)
51

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MLH3	MLH1
Gene Name		mutL homolog 3	mutL homolog 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Chiasma Mismatch Repair Complex	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex
	Molecular Function	Chromatin Binding Satellite DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis Female Meiosis I Protein Localization	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly
Pathways		Meiotic recombination	Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		4 interactors: AR MLH1 MSH4 ZDHHC17	74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1
Entrez ID		27030	4292
HPRD ID		05094	00390
Ensembl ID		ENSG00000119684	ENSG00000076242
Uniprot IDs		Q2M1Z1 Q9UHC1	P40692 Q59EG3
PDB IDs			3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Reciprocal Meiotic Recombination Synapsis Homologous Chromosome Segregation Meiotic Chromosome Segregation Developmental Process Involved In Reproduction Meiosis I Female Gamete Generation Negative Regulation Of Integrin Biosynthetic Process Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Meiotic Nuclear Division Negative Regulation Of Mitotic Recombination Meiotic Cell Cycle Positive Regulation Of Integrin Biosynthetic Process Single Organism Reproductive Process Chromosome Segregation DNA Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Regulation Of Integrin Biosynthetic Process Reproductive Process Sex Differentiation Chiasma Assembly Spindle Midzone Assembly Positive Regulation Of Transcription From RNA Polymerase III Promoter Resolution Of Meiotic Recombination Intermediates Cellular Component Assembly Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Reproductive Structure Development Reproductive System Development Spermatogenesis Male Gamete Generation Lipoprotein Transport Magnesium Ion Transport Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Regulation Of Transcription From RNA Polymerase III Promoter Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Gamete Generation Protein Palmitoylation Metaphase Plate Congression Somatic Recombination Of Immunoglobulin Gene Segments Androgen Receptor Signaling Pathway Somatic Diversification Of Immunoglobulins Sexual Reproduction Multicellular Organismal Reproductive Process Regulation Of Establishment Of Protein Localization To Plasma Membrane	Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction
Tagcloud ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh1 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Difference) ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify
Tagcloud (Intersection) ?		mlh1