MLH3 and EXO1

Number of citations of the paper that reports this interaction (PubMedID 32814904)
0

Data Source:
BioGRID (pull down)

		MLH3	EXO1
Description		mutL homolog 3	exonuclease 1
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Nucleus Nucleoplasm Plasma Membrane Nuclear Body
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	DNA Binding Chromatin Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity 5'-3' DNA Exonuclease Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' DNA Exonuclease Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization	Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle T-circle Formation DNA Strand Resection Involved In Replication Fork Processing
Pathways		Meiotic recombination	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	20 interacting genes: ATM BLM DCAF1 H4C1 KPNA4 KPNB1 MLH1 MLH3 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		27030	9156
HPRD ID		05094	06932
Ensembl ID		ENSG00000119684	ENSG00000174371
Uniprot IDs		Q2M1Z1 Q9UHC1	A8K5H6 Q9UQ84
PDB IDs			3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E 7MXQ 7MXR 7MXS 7MXT 7MXU 7MXV 7MXW 7MXX
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Mismatch Repair Mismatched DNA Binding Somatic Cell DNA Recombination ATP-dependent DNA Damage Sensor Activity Phosphoserine Residue Binding DNA Recombination Protein Sequestering Activity Dinucleotide Insertion Or Deletion Binding Chromosome Organization Negative Regulation Of DNA Recombination Guanine/thymine Mispair Binding Enzyme Binding Regulation Of DNA Recombination Mismatch Repair Complex Cellular Response To Stress Positive Regulation Of Isotype Switching To IgA Isotypes DNA Metabolic Process DNA Repair Somatic Recombination Of Immunoglobulin Gene Segments Nucleus DNA Damage Response Single-stranded DNA Binding Protein Domain Specific Binding Somatic Diversification Of Immunoglobulins Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Isotype Switching To IgG Isotypes Male Germ Cell Nucleus Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of DNA Metabolic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Isotype Switching To IgG Isotypes Regulation Of DNA Metabolic Process Intracellular Protein Localization Nucleoplasm Chiasma MutSbeta Complex Dinucleotide Repeat Insertion Binding Chromosome, Telomeric Region Positive Regulation Of Hippo Signaling Positive Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Synaptonemal Complex Protein Kinase C Inhibitor Activity MutLalpha Complex Single Guanine Insertion Binding Response To X-ray Reciprocal Meiotic Recombination Positive Regulation Of Isotype Switching Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process
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