MLH3 and FRAT2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		MLH3	FRAT2
Description		mutL homolog 3	FRAT regulator of Wnt signaling pathway 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization	Wnt Signaling Pathway Regulation Of Protein Export From Nucleus Canonical Wnt Signaling Pathway
Pathways		Meiotic recombination	Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Body mass index ( 28892062) General risk tolerance (MTAG) ( 30643258) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte count ( 32888494)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	12 interacting genes: BUB1 CDKN2A CTNNA1 EGFR ERBB2 GSK3B KRAS MCC MLH1 MLH3 NRAS PTPN12
Entrez ID		27030	23401
HPRD ID		05094	05419
Ensembl ID		ENSG00000119684	ENSG00000181274
Uniprot IDs		Q2M1Z1 Q9UHC1	O75474
PDB IDs
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Chiasma Intracellular Signal Transduction Negative Regulation Of Cell Differentiation Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Mismatch Repair Complex Response To Epidermal Growth Factor Negative Regulation Of Immature T Cell Proliferation Intracellular Signaling Cassette ERBB2-EGFR Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of T Cell Differentiation In Thymus Ras Protein Signal Transduction Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Cell Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mismatched DNA Binding Signal Transduction Regulation Of Cell Population Proliferation Nucleotide Binding Apoptotic Signaling Pathway Negative Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Population Proliferation Positive Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of Cell Growth Synaptonemal Complex Regulation Of Cell Development Regulation Of Protein Localization To Nucleus Focal Adhesion ATP Binding Reciprocal Meiotic Recombination Regulation Of Signal Transduction NF-kappaB Binding Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of ERBB Signaling Pathway Mismatch Repair Condensed Chromosome Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cytosol Regulation Of Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?