MLH1 and IGKC

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MLH1	IGKC
Gene Name		mutL homolog 1	immunoglobulin kappa constant
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	Antigen Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	Retina Homeostasis Receptor-mediated Endocytosis Immune Response Complement Activation Complement Activation, Classical Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Immune Response
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	4 interactors: CD40LG IGHG1 MLH1 SMARCD1
Entrez ID		4292	3514
HPRD ID		00390	00921
Ensembl ID		ENSG00000076242
Uniprot IDs		P40692 Q59EG3
PDB IDs		3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Isotype Switching Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Immunoglobulin Production Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Leukocyte Activation Involved In Immune Response B Cell Activation Negative Regulation Of Mitotic Recombination DNA Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Immune Response Immunoglobulin Secretion Spindle Midzone Assembly Lymphocyte Activation Chromatin-mediated Maintenance Of Transcription Positive Regulation Of Endothelial Cell Apoptotic Process Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Leukocyte Activation Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Immunoglobulin Secretion Nucleosome Disassembly Immune System Process Positive Regulation Of Gene Expression, Epigenetic Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Cell Activation Immune System Development Metaphase Plate Congression Regulation Of Endothelial Cell Apoptotic Process B Cell Proliferation Establishment Of Chromosome Localization Reciprocal Meiotic Recombination Positive Regulation Of Interleukin-12 Production Regulation Of Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Synapsis Mismatch Repair Homologous Chromosome Segregation
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 cd8a ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 cd8a ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic ido1 immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable
Tagcloud (Intersection) ?