MLH3 and FBP2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		MLH3	FBP2
Description		mutL homolog 3	fructose-bisphosphatase 2
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Z Disc Extracellular Exosome Anchoring Junction
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Catalytic Activity Protein Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Fructose 1,6-bisphosphate Metabolic Process
Pathways		Meiotic recombination	Gluconeogenesis
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Caudal middle frontal gyrus volume ( 31530798) Colorectal cancer (alcohol consumption interaction) ( 27723779) Height ( 19893584)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	19 interacting genes: AURKA AXIN2 BMPR1A BUB1 CHD3 CTNNA1 DLC1 FBXW7 MAP2K4 MLH3 MSH2 NRAS PDGFRL PIK3CA RB1 SMAD2 SMAD4 SRC STK11
Entrez ID		27030	8789
HPRD ID		05094	04322
Ensembl ID		ENSG00000119684	ENSG00000130957
Uniprot IDs		Q2M1Z1 Q9UHC1	O00757
PDB IDs			3IFA 3IFC 4HE0 4HE1 4HE2 5ET5 5ET6 5ET7 5ET8 5K54 5K55 5K56 5L0A 5Q0C
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Regulation Of Developmental Process Axis Specification Chromosome Organization Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Dorsal/ventral Axis Specification Heart Valve Morphogenesis I-SMAD Binding ATP Binding Intracellular Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Cellular Component Organization Regulation Of Cell Development Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Kinase Activity Organelle Organization Regulation Of Organelle Organization Activin Responsive Factor Complex Odontogenesis Protein Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Nucleotide Binding Endoderm Development Regulation Of Chromosome Organization Reproductive Process Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cell Cycle Anatomical Structure Morphogenesis Protein Kinase Activity Centromeric DNA Binding Regulation Of Multicellular Organismal Process Ubiquitin Protein Ligase Binding SMAD Binding Regulation Of Cellular Component Organization Response To Growth Factor Mesendoderm Development SMAD Protein Complex Maintenance Of DNA Repeat Elements Regulation Of Signal Transduction
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