MLH3

Gene Name		mutL homolog 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Chiasma Mismatch Repair Complex
	Molecular Function	Chromatin Binding Satellite DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis Female Meiosis I Protein Localization
Pathways		Meiotic recombination
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-protein Interactions		4 interactors: AR MLH1 MSH4 ZDHHC17
Entrez ID		27030
HPRD ID		05094
Ensembl ID		ENSG00000119684
Uniprot IDs		Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Reciprocal Meiotic Recombination Synapsis Homologous Chromosome Segregation Meiotic Chromosome Segregation Developmental Process Involved In Reproduction Meiosis I Female Gamete Generation Negative Regulation Of Integrin Biosynthetic Process Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Meiotic Nuclear Division Negative Regulation Of Mitotic Recombination Meiotic Cell Cycle Positive Regulation Of Integrin Biosynthetic Process Single Organism Reproductive Process Chromosome Segregation DNA Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Regulation Of Integrin Biosynthetic Process Reproductive Process Sex Differentiation Chiasma Assembly Spindle Midzone Assembly Positive Regulation Of Transcription From RNA Polymerase III Promoter Resolution Of Meiotic Recombination Intermediates Cellular Component Assembly Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Reproductive Structure Development Reproductive System Development Spermatogenesis Male Gamete Generation Lipoprotein Transport Magnesium Ion Transport Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Regulation Of Transcription From RNA Polymerase III Promoter Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Gamete Generation Protein Palmitoylation Metaphase Plate Congression Somatic Recombination Of Immunoglobulin Gene Segments Androgen Receptor Signaling Pathway Somatic Diversification Of Immunoglobulins Sexual Reproduction Multicellular Organismal Reproductive Process Regulation Of Establishment Of Protein Localization To Plasma Membrane
Tagcloud ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh1 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e