MLH3 and MSANTD3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		MLH3	MSANTD3
Description		mutL homolog 3	Myb/SANT DNA binding domain containing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Protein Binding
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization
Pathways		Meiotic recombination
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Conjunctival UV autofluorescence (CUVAF) ( 25590795)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	16 interacting genes: BMPR1A BUB1 CDH1 FXR1 FXR2 GNAS MCC MLH3 MUTYH PFN2 SMAD4 SUV39H1 TMEM129 TSC1 VSTM2A ZDHHC17
Entrez ID		27030	91283
HPRD ID		05094	14459
Ensembl ID		ENSG00000119684	ENSG00000066697
Uniprot IDs		Q2M1Z1 Q9UHC1	Q96H12
PDB IDs
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Cellular Response To BMP Stimulus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Mesendoderm Development Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Multicellular Organismal Process Postsynapse Modulation Of Chemical Synaptic Transmission Cardiac Conduction System Development Negative Regulation Of Epithelial Cell Migration Translation Regulator Activity Animal Organ Development Regulation Of Growth Regulation Of Developmental Growth Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Locomotion Outflow Tract Septum Morphogenesis Regulation Of Neurogenesis Mismatch Repair Positive Regulation Of Cellular Component Organization Pituitary Gland Development Endoderm Development Regulation Of Multicellular Organismal Process Regulation Of Neural Crest Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Cellular Senescence Ventricular Septum Morphogenesis Regulation Of Cell Development Regulation Of Developmental Process SMAD Binding Ventricular Cardiac Muscle Tissue Morphogenesis Neural Plate Mediolateral Regionalization Paraxial Mesoderm Structural Organization Positive Regulation Of Cell Differentiation Fibrous Ring Of Heart Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Lamellipodium Cardiocyte Differentiation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
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