MLH1 and ZNF774

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MLH1	ZNF774
Description		mutL homolog 1	zinc finger protein 774
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Chiasma Late Recombination Nodule Membrane Nuclear Lumen Mismatch Repair Complex MutLalpha Complex	Nucleus
	Molecular Function	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress DNA Damage Response Male Meiosis Chromosome Segregation Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Meiotic Metaphase I Homologous Chromosome Alignment Meiotic Chromosome Segregation Meiotic Telomere Clustering Homologous Chromosome Segregation Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly Meiotic Cell Cycle	Regulation Of Transcription By RNA Polymerase II
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination	Generic Transcription Pathway
Drugs
Diseases		Ovarian cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer Endometrial Cancer
GWAS		Alanine aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Liver enzyme levels (alanine transaminase) ( 33972514) Platelet distribution width ( 32888494) Proximal colorectal cancer ( 33632709) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)	Male-pattern baldness ( 28196072) Rheumatoid arthritis ( 22446963)
Interacting Genes		139 interacting genes: - ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ALDOB ANXA6 AP1B1 AP2B1 APRT ARAF ASS1 ATF2 BAAT BLM BRCA1 BTBD2 C9orf152 CAB39L CAPN5 CASP3 CBY2 CCDC180 CCDC33 CCDC74B CDCA7L CDKL5 CEP126 CEP76 CKAP4 CKB CTSV CYLC2 DDX47 EEF1G EEF2 EIF2A ELP6 ENKD1 EXO1 EXOC3 FAM228A FAM50B FAM90A1 FBXO32 FCGBP FLNB FRAT2 FRMD6 GABARAP GSTP1 HDAC6 IGKC ISY1 KPNA2 KPNA5 KPRP LEF1 LGALS4 LUC7L3 LY96 MAGEA8 MAP2K6 MBD3L1 MBD4 MLH3 MORN3 MPG MSH2 MSH3 MSH4 MSH5 MUC2 MYC MYL6 MYOG NANOS3 NDRG1 NELFA NME4 NT5C3B ORC4 PARP12 PARVA PCNA PER2 PIP4K2B PMS1 PMS2 PPP1R13B PPP2CB PRR5L PSMA1 PTGDS PTPN3 PTPRH RAD23B RAD9A RADX RAPGEFL1 RBM48 RSPH3 SEC61A1 SELENBP1 SERPINF1 SMAD1 SPATA8 SQSTM1 STAP2 STX17 SYF2 TASOR2 TDRD7 TFAP2D TLE5 TRIM23 TRIM29 TRMO TSGA13 TXN TXN2 U2AF1 UBOX5 VAMP8 XPA ZBED1 ZC3H11A ZER1 ZFP57 ZFP90 ZMAT5 ZNF177 ZNF212 ZNF474 ZNF559-ZNF177 ZNF774	77 interacting genes: BACH2 BEGAIN BLK BOLA2 BOLA2B CABP2 CALCOCO2 CARD9 CATSPER1 CCDC102B CCDC136 CCDC6 CCHCR1 CDK18 CDKN2D CEP63 CIB3 COL8A1 CPNE7 DTX2 DVL3 EFEMP2 EMD FAM124B FSD2 GABARAPL2 GEM GFAP GLRX3 GOLGA1 GOLGA2 GTPBP3 GYS1 GZMM HOXA1 HOXB5 HSF2BP IL16 IPO8 KANK2 KIFC3 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP4-5 LDOC1 LONRF1 MAGOHB MID2 MLH1 MTUS2 MYO15B NDOR1 NEK6 NID2 PIBF1 PICK1 PRPF31 PSMB1 RABEP1 RAD51D RBM11 SCNM1 SH2D4A SMAD3 STK16 TRAF2 TSTD2 USP49 VWC2 YJU2B ZNF165 ZNF417 ZNF48 ZNF526 ZNF572 ZNF587
Entrez ID		4292	342132
HPRD ID		00390	17571
Ensembl ID		ENSG00000076242	ENSG00000196391
Uniprot IDs		A0A087WX20 A0A669KAW3 A0AAQ5BGN3 A0AAQ5BGZ2 H0Y818 P40692 Q59EG3	Q6NX45
PDB IDs		3RBN 4P7A 5U5P 6WBA 6WBB 6WBC 7M60
Enriched GO Terms of Interacting Partners?		Mismatch Repair Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Cellular Response To Stress Apoptotic Signaling Pathway Response To Estradiol DNA Damage Response Dinucleotide Insertion Or Deletion Binding Intrinsic Apoptotic Signaling Pathway Response To Corticosteroid DNA Repair Mismatch Repair Complex DNA Metabolic Process Protein Binding Response To Glucocorticoid Damaged DNA Binding Response To Hydrogen Peroxide Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Response To Dexamethasone Mitotic DNA Integrity Checkpoint Signaling Somatic Cell DNA Recombination Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Response To Reactive Oxygen Species MutSbeta Complex Dinucleotide Repeat Insertion Binding Response To Steroid Hormone Nucleus Response To Stress Somatic Hypermutation Of Immunoglobulin Genes DNA Recombination DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Fructose-bisphosphate Aldolase Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Single Guanine Insertion Binding MutLalpha Complex Response To Oxidative Stress Cellular Response To Corticosteroid Stimulus Mucus Secretion Response To Radiation Single-stranded DNA Binding P53 Binding Response To UV Mitotic Intra-S DNA Damage Checkpoint Signaling Signal Sequence Binding Guanine/thymine Mispair Binding Satellite DNA Binding Somatic Diversification Of Immunoglobulins	Protein Binding Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex
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