MLH1 and EXOC3

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MLH1	EXOC3
Gene Name		mutL homolog 1	exocyst complex component 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Exocyst Cytosol Secretory Granule Membrane
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	SNARE Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Exocyst Localization Membrane Organization
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing
Drugs
Diseases
GWAS			Ulcerative colitis ( 21297633)
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	6 interactors: APP BIRC6 BUB3 EXOC2 MLH1 RALA
Entrez ID		4292	11336
HPRD ID		00390	09738
Ensembl ID		ENSG00000076242	ENSG00000180104
Uniprot IDs		P40692 Q59EG3	O60645 Q69YP2
PDB IDs		3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Cell Cycle Process Exocytosis Cellular Localization Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Cell Division Cell Cycle MRNA 3'-end Processing Regulation Of Cell Cycle Process Secretion By Cell Organelle Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression RNA 3'-end Processing Secretion Regulation Of Proteolysis Negative Regulation Of Mitotic Recombination Synaptic Growth At Neuromuscular Junction Microtubule-based Process Negative Regulation Of Catalytic Activity Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Recombination Membrane Raft Localization Male Meiosis Chromosome Segregation Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Meiotic Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Segregation Regulation Of Cell Cycle Phase Transition Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Reproduction Cell Death Death Axon Choice Point Recognition Regulation Of Cell Division Negative Regulation Of Endopeptidase Activity Cytoskeleton Organization Negative Regulation Of Peptidase Activity Spindle Midzone Assembly Neuron Remodeling Mitotic Nuclear Division
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	bioactive chemoattractive chemokine chemotactic constitutively cxcl16 dc dendritic dithiocarbamate functionally healing lipopolysaccharide lysoptdoh macrophages mediator modc monocyte organs pertussis pyrrolidine reflected rho secrete separately toxin trafficking transmembrane twofold wound
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	bioactive chemoattractive chemokine chemotactic constitutively cxcl16 dc dendritic dithiocarbamate functionally healing lipopolysaccharide lysoptdoh macrophages mediator modc monocyte organs pertussis pyrrolidine reflected rho secrete separately toxin trafficking transmembrane twofold wound
Tagcloud (Intersection) ?