MLH1 and ABHD16A

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MLH1	ABHD16A
Gene Name		mutL homolog 1	abhydrolase domain containing 16A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Integral Component Of Membrane
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	Metabolic Process
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	19 interactors: ATP5G3 DNAJC1 DTX2 FAM134C GPRC5C HM13 HNRNPA1 IFITM1 MLH1 ND3 ND4 PILRB PTGS2 RNF5 SAFB SPAG7 TMEM147 TMEM222 UPF1
Entrez ID		4292	7920
HPRD ID		00390	15929
Ensembl ID		ENSG00000076242	ENSG00000204427
Uniprot IDs		P40692 Q59EG3	B3KNX9 O95870
PDB IDs		3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Respiratory Electron Transport Chain Electron Transport Chain ATP Metabolic Process Cellular Respiration Mitochondrial Electron Transport, NADH To Ubiquinone Nucleotide Metabolic Process Purine Nucleoside Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Mitochondrial ATP Synthesis Coupled Electron Transport Maintenance Of Blood-brain Barrier Meiotic Metaphase I Plate Congression Meiotic Spindle Midzone Assembly Ribonucleotide Metabolic Process Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Oxidative Phosphorylation RNA Export From Nucleus Negative Regulation Of Mitotic Recombination ER-associated Misfolded Protein Catabolic Process Positive Regulation Of Fibroblast Growth Factor Production Generation Of Precursor Metabolites And Energy Female Gamete Generation Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Production Nuclear Export MRNA Transport Posttranscriptional Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Organophosphate Metabolic Process RNA Transport Positive Regulation Of Brown Fat Cell Differentiation Nuclear-transcribed MRNA Catabolic Process RNA Localization Heterocycle Metabolic Process MRNA Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Prostaglandin Biosynthetic Process MRNA Catabolic Process Positive Regulation Of Synaptic Plasticity Spindle Midzone Assembly Positive Regulation Of Sprouting Angiogenesis Cellular Nitrogen Compound Metabolic Process RNA Catabolic Process
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	15d abpp bat5 c14 c18 c20 c7600 dag delta12 diacylglycerol ebelactone genuine glycerolipid hbat5 j2 linoleylglycerol lysophospholipase mag mags monoacylglycerols oxadiazol palmostatin pave pgj2 phenoxyphenyl tetrahydrolipstatin triacylglycerol unveiling
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	15d abpp bat5 c14 c18 c20 c7600 dag delta12 diacylglycerol ebelactone genuine glycerolipid hbat5 j2 linoleylglycerol lysophospholipase mag mags monoacylglycerols oxadiazol palmostatin pave pgj2 phenoxyphenyl tetrahydrolipstatin triacylglycerol unveiling
Tagcloud (Intersection) ?