MLH1 and FBXO32

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MLH1	FBXO32
Gene Name		mutL homolog 1	F-box protein 32
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Nucleolus Z Disc
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Cellular Response To Dexamethasone Stimulus
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	6 interactors: CDC34 EIF3A EIF3F MLH1 SKP1 UBE2D3
Entrez ID		4292	114907
HPRD ID		00390	05966
Ensembl ID		ENSG00000076242	ENSG00000156804
Uniprot IDs		P40692 Q59EG3	I6L984 Q0VAQ6 Q498Y9 Q969P5
PDB IDs		3NA3 3RBN
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Formation Of Translation Preinitiation Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Regulation Of Translational Initiation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteolysis Cellular Protein Catabolic Process Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Macromolecular Complex Assembly Catabolic Process Negative Regulation Of Mitotic Recombination G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Ribonucleoprotein Complex Assembly Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Cellular Protein Metabolic Process Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Cell Cycle Process DNA Metabolic Process Positive Regulation Of Inclusion Body Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of CAMP-mediated Signaling Regulation Of Translation Spindle Midzone Assembly Mature Ribosome Assembly Ribosomal Subunit Export From Nucleus Cytoplasmic Translational Initiation Ribonucleoprotein Complex Biogenesis Establishment Of Organelle Localization Resolution Of Meiotic Recombination Intermediates Histone H2A Monoubiquitination Cell Cycle Protein Metabolic Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Histone H2A Ubiquitination Cytoplasmic Translation Cellular Protein Modification Process
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	ameliorated aquafeeds catabolic daidzein determines equol extend fishmeal genistein glycitein greatest ici legumes mitogenic mum mykiss myocyte nutrient oncorhynchus phytoestrogen phytoestrogens rainbow replacements salmonid soy soybeans trout turnover warrant
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	ameliorated aquafeeds catabolic daidzein determines equol extend fishmeal genistein glycitein greatest ici legumes mitogenic mum mykiss myocyte nutrient oncorhynchus phytoestrogen phytoestrogens rainbow replacements salmonid soy soybeans trout turnover warrant
Tagcloud (Intersection) ?