MLH3 and MSH4

Number of citations of the paper that reports this interaction (PMID 12095912)
18

Data Source:
HPRD (in vitro)

		MLH3	MSH4
Gene Name		mutL homolog 3	mutS homolog 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Chiasma Mismatch Repair Complex	Synaptonemal Complex Nucleus Mismatch Repair Complex
	Molecular Function	Chromatin Binding Satellite DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding	DNA Binding Damaged DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Mismatched DNA Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis Female Meiosis I Protein Localization	Meiotic Mismatch Repair Ovarian Follicle Development Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation Homologous Chromosome Segregation Chiasma Assembly
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		4 interactors: AR MLH1 MSH4 ZDHHC17	5 interactors: MLH1 MLH3 MSH5 RPA1 VBP1
Entrez ID		27030	4438
HPRD ID		05094	03658
Ensembl ID		ENSG00000119684	ENSG00000057468
Uniprot IDs		Q2M1Z1 Q9UHC1	O15457
PDB IDs
Enriched GO Terms of Interacting Partners?		Reciprocal Meiotic Recombination Synapsis Homologous Chromosome Segregation Meiotic Chromosome Segregation Developmental Process Involved In Reproduction Meiosis I Female Gamete Generation Negative Regulation Of Integrin Biosynthetic Process Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Meiotic Nuclear Division Negative Regulation Of Mitotic Recombination Meiotic Cell Cycle Positive Regulation Of Integrin Biosynthetic Process Single Organism Reproductive Process Chromosome Segregation DNA Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Regulation Of Integrin Biosynthetic Process Reproductive Process Sex Differentiation Chiasma Assembly Spindle Midzone Assembly Positive Regulation Of Transcription From RNA Polymerase III Promoter Resolution Of Meiotic Recombination Intermediates Cellular Component Assembly Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Reproductive Structure Development Reproductive System Development Spermatogenesis Male Gamete Generation Lipoprotein Transport Magnesium Ion Transport Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Regulation Of Transcription From RNA Polymerase III Promoter Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Gamete Generation Protein Palmitoylation Metaphase Plate Congression Somatic Recombination Of Immunoglobulin Gene Segments Androgen Receptor Signaling Pathway Somatic Diversification Of Immunoglobulins Sexual Reproduction Multicellular Organismal Reproductive Process Regulation Of Establishment Of Protein Localization To Plasma Membrane	Mismatch Repair Meiotic Nuclear Division Meiotic Cell Cycle Reciprocal Meiotic Recombination DNA Recombination Synapsis Homologous Chromosome Segregation Meiotic Chromosome Segregation Meiosis I DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Segregation Chromosome Organization Reproduction Cell Cycle Process DNA Metabolic Process Cell Cycle Male Meiosis Cellular Response To Stress Cellular Component Assembly Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Double-strand Break Repair Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation DNA Recombinase Assembly Organelle Organization Chiasma Assembly Spindle Midzone Assembly Response To Stress Female Meiosis I Resolution Of Meiotic Recombination Intermediates Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Aromatic Compound Catabolic Process Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Synaptonemal Complex Assembly Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Synaptonemal Complex Organization Nuclear DNA Replication Telomere Maintenance Via Recombination Nuclear-transcribed MRNA Poly(A) Tail Shortening Isotype Switching Nucleobase-containing Compound Metabolic Process Mitotic Recombination
Tagcloud ?		aggregated anaplastic atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive exome harbored hypermutator landscape mismatch mlh1 msh5 msh6 mutational mutually nf1 nf2 nras ontology pik3ca ret unresponsive ush2a v600e	2480delg 2480t 286c anaplastic astrocytomas codon contributed exceptionally exome fraumeni germline glioblastomas gliomas i827n inherited lats1 li missense mutational neurofibroma nf2 r827kfs r96w schwannoma schwannomas schwannomatosis sporadic stop tp53
Tagcloud (Difference) ?		aggregated atc braf cdkn1b cdkn2c ctnnb1 eif1ax exclusive harbored hypermutator landscape mismatch mlh1 msh5 msh6 mutually nf1 nras ontology pik3ca ret unresponsive ush2a v600e	2480delg 2480t 286c astrocytomas codon contributed exceptionally fraumeni germline glioblastomas gliomas i827n inherited lats1 li missense neurofibroma r827kfs r96w schwannoma schwannomas schwannomatosis sporadic stop tp53
Tagcloud (Intersection) ?		anaplastic exome mutational nf2