MLH3 and GALNT12

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		MLH3	GALNT12
Description		mutL homolog 3	polypeptide N-acetylgalactosaminyltransferase 12
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		Meiotic recombination	Defective GALNT12 causes CRCS1 O-linked glycosylation of mucins
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Asthma ( 31959851) Autism spectrum disorder ( 34069769) Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Left–right brain asymmetry ( 33723403) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	16 interacting genes: APP BMPR1A BUB1 CDH1 CDKN2A FBXW7 MLH3 MSH2 MUC1 MUC2 MUC5AC MUC7 PIK3CA PMS2 RB1 SRC
Entrez ID		27030	79695
HPRD ID		05094	13561
Ensembl ID		ENSG00000119684	ENSG00000119514
Uniprot IDs		Q2M1Z1 Q9UHC1	Q8IXK2
PDB IDs			6PXU
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Golgi Lumen Mismatched DNA Binding Regulation Of Mitotic Cell Cycle ATP-dependent DNA Damage Sensor Activity Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Cell Cycle Phase Transition Mismatch Repair Negative Regulation Of Cell Development Homeostatic Process Regulation Of Growth Regulation Of Developmental Process Regulation Of Protein Localization To Nucleus Chromosome Organization Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding Mismatch Repair Complex Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Signaling Receptor Activator Activity Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Biosynthetic Process Regulation Of Immune System Process Regulation Of Cell Cycle Process Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Localization Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cell Cycle Phase Transition Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Multicellular Organismal Process Regulation Of Neuron Apoptotic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Intracellular Signal Transduction Regulation Of Isotype Switching To IgG Isotypes Cellular Response To Oxygen-containing Compound Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Response To Stress ATP Binding Negative Regulation Of Anoikis Negative Regulation Of Macromolecule Metabolic Process
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