MLH1 and RAD23B

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MLH1	RAD23B
Gene Name		mutL homolog 1	RAD23 homolog B (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm XPC Complex
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Spermatogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER DNA Damage Recognition in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS			Body mass index ( 20966902) Breast cancer ( 21263130) Prostate cancer ( 23023329)
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	20 interactors: ADRM1 ATXN3 CALM1 DBI DEAF1 HMGB1 MLH1 MPG NGLY1 PAX3 PNMA5 PSMD4 PUF60 RPA1 TDG UBA2 UBB UBE3A XPC ZFAND5
Entrez ID		4292	5887
HPRD ID		00390	06772
Ensembl ID		ENSG00000076242	ENSG00000119318
Uniprot IDs		P40692 Q59EG3	B7Z4W4 P54727
PDB IDs		3NA3 3RBN	1P1A 1PVE 1UEL
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Cellular Macromolecule Catabolic Process Catabolic Process Cellular Response To DNA Damage Stimulus DNA Repair DNA Catabolic Process Base-excision Repair DNA Metabolic Process Nitrogen Compound Metabolic Process Aromatic Compound Catabolic Process Cellular Response To Stress Response To Stress Cellular Nitrogen Compound Metabolic Process Protein Catabolic Process Mismatch Repair Cellular Metabolic Process Base-excision Repair, AP Site Formation Modification-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair Mitotic DNA Damage Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Mitotic DNA Integrity Checkpoint Multicellular Organismal Development Positive Regulation Of Proteolysis Heterocycle Metabolic Process Deoxyribose Phosphate Catabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Nucleotide-excision Repair, DNA Damage Removal Anatomical Structure Development Programmed Cell Death System Development Cell Death Death Negative Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Response To Abiotic Stimulus Deoxyribonucleotide Catabolic Process DNA Damage Checkpoint Nervous System Development G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Developmental Process Behavioral Fear Response Fear Response Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Process
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	a3 adoptive bioinformatic blunting dige diploid disulfide excision galactosidase hnrnpa3 hnrnpq imr90 isomerase lesser mir mirrored pdia3 permanent perturbation proteome ribonucleoprotein senescence senescent slowed synaptotagmin syncrip untranslated utrs
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	a3 adoptive bioinformatic blunting dige diploid disulfide excision galactosidase hnrnpa3 hnrnpq imr90 isomerase lesser mir mirrored pdia3 permanent perturbation proteome ribonucleoprotein senescence senescent slowed synaptotagmin syncrip untranslated utrs
Tagcloud (Intersection) ?