Wiki-Pi
About
Search
People
Updates
Search
MLH1 and GSTP1
Number of citations of the paper that reports this interaction (PubMedID
20706999
)
0
Data Source:
BioGRID
(two hybrid)
MLH1
GSTP1
Description
mutL homolog 1
glutathione S-transferase pi 1
Image
GO Annotations
Cellular Component
Condensed Chromosome
Condensed Nuclear Chromosome
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Chiasma
Late Recombination Nodule
Membrane
Nuclear Lumen
Mismatch Repair Complex
MutLalpha Complex
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Vesicle
Secretory Granule Lumen
Extracellular Exosome
TRAF2-GSTP1 Complex
Ficolin-1-rich Granule Lumen
Molecular Function
Nucleotide Binding
Chromatin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP Hydrolysis Activity
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
ATP-dependent DNA Damage Sensor Activity
Glutathione Transferase Activity
Glutathione Peroxidase Activity
Fatty Acid Binding
Protein Binding
JUN Kinase Binding
Toxic Substance Binding
Transferase Activity
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
S-nitrosoglutathione Binding
Dinitrosyl-iron Complex Binding
Nitric Oxide Binding
Biological Process
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response
DNA Repair
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Response To Stress
DNA Damage Response
Male Meiosis Chromosome Segregation
Homologous Chromosome Pairing At Meiosis
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Bacterium
Female Meiosis Chromosome Segregation
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
Meiotic Metaphase I Homologous Chromosome Alignment
Meiotic Chromosome Segregation
Meiotic Telomere Clustering
Homologous Chromosome Segregation
Isotype Switching
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Oogenesis
Meiotic Spindle Midzone Assembly
Meiotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Response To Reactive Oxygen Species
Negative Regulation Of Acute Inflammatory Response
Lipid Metabolic Process
Prostaglandin Metabolic Process
Glutathione Metabolic Process
Xenobiotic Metabolic Process
Central Nervous System Development
Response To Toxic Substance
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Oligodendrocyte Development
Animal Organ Regeneration
Response To Nutrient Levels
Response To Estradiol
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Superoxide Anion Generation
Response To L-ascorbic Acid
Common Myeloid Progenitor Cell Proliferation
Nitric Oxide Storage
Negative Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Negative Regulation Of MAPK Cascade
Linoleic Acid Metabolic Process
Response To Ethanol
Negative Regulation Of JNK Cascade
Negative Regulation Of Fibroblast Proliferation
Hepoxilin Biosynthetic Process
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Leukocyte Proliferation
Cellular Response To Lipopolysaccharide
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Cell-matrix Adhesion
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Negative Regulation Of Smooth Muscle Cell Chemotaxis
Cellular Oxidant Detoxification
Glutathione Derivative Biosynthetic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
TP53 Regulates Transcription of DNA Repair Genes
Meiotic recombination
Glutathione conjugation
Detoxification of Reactive Oxygen Species
Neutrophil degranulation
Paracetamol ADME
Drugs
Glutathione
Troglitazone
Clozapine
Etacrynic acid
Clomipramine
(9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene
S-Hydroxycysteine
Cibacron Blue
Glutathione sulfonic acid
Glutathione disulfide
Deoxycholic acid
Deoxycholic acid
S-(4-nitrobenzyl)glutathione
2-(N-morpholino)ethanesulfonic acid
S-Hexylglutathione
Canfosfamide
Ezatiostat
Exisulind
S-NONYL-CYSTEINE
S-(4-BROMOBENZYL)CYSTEINE
Curcumin
Dinitrochlorobenzene
Hypericin
Curcumin sulfate
Diseases
Ovarian cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Colorectal cancer
Endometrial Cancer
Prostate cancer
GWAS
Alanine aminotransferase levels (
33547301
)
Autism spectrum disorder or schizophrenia (
28540026
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Platelet distribution width (
32888494
)
Proximal colorectal cancer (
33632709
)
Schizophrenia (
28991256
)
Subjective response to lithium treatment (
26503763
)
A body shape index (
34021172
)
Hip circumference adjusted for BMI (
34021172
)
Refractive error (
32231278
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
139 interacting genes:
-
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ALDOB
ANXA6
AP1B1
AP2B1
APRT
ARAF
ASS1
ATF2
BAAT
BLM
BRCA1
BTBD2
C9orf152
CAB39L
CAPN5
CASP3
CBY2
CCDC180
CCDC33
CCDC74B
CDCA7L
CDKL5
CEP126
CEP76
CKAP4
CKB
CTSV
CYLC2
DDX47
EEF1G
EEF2
EIF2A
ELP6
ENKD1
EXO1
EXOC3
FAM228A
FAM50B
FAM90A1
FBXO32
FCGBP
FLNB
FRAT2
FRMD6
GABARAP
GSTP1
HDAC6
IGKC
ISY1
KPNA2
KPNA5
KPRP
LEF1
LGALS4
LUC7L3
LY96
MAGEA8
MAP2K6
MBD3L1
MBD4
MLH3
MORN3
MPG
MSH2
MSH3
MSH4
MSH5
MUC2
MYC
MYL6
MYOG
NANOS3
NDRG1
NELFA
NME4
NT5C3B
ORC4
PARP12
PARVA
PCNA
PER2
PIP4K2B
PMS1
PMS2
PPP1R13B
PPP2CB
PRR5L
PSMA1
PTGDS
PTPN3
PTPRH
RAD23B
RAD9A
RADX
RAPGEFL1
RBM48
RSPH3
SEC61A1
SELENBP1
SERPINF1
SMAD1
SPATA8
SQSTM1
STAP2
STX17
SYF2
TASOR2
TDRD7
TFAP2D
TLE5
TRIM23
TRIM29
TRMO
TSGA13
TXN
TXN2
U2AF1
UBOX5
VAMP8
XPA
ZBED1
ZC3H11A
ZER1
ZFP57
ZFP90
ZMAT5
ZNF177
ZNF212
ZNF474
ZNF559-ZNF177
ZNF774
39 interacting genes:
ADAMTSL4
APPBP2
CARD10
CEBPA
CYSRT1
FANCC
FBXO8
FHL5
HOXA1
KRT31
KRT33B
KRT34
KRT83
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-9
KRTAP3-1
KRTAP3-3
KRTAP6-2
LRP2BP
MAPK8
MLH1
MTUS2
NBPF19
NOTCH2NLA
OGT
PNO1
PRDX6
PTN
RNF26
SCAF1
SH3GLB1
SUMO4
TGM1
TGM2
TRAF2
ZNF655
Entrez ID
4292
2950
HPRD ID
00390
00614
Ensembl ID
ENSG00000076242
ENSG00000084207
Uniprot IDs
A0A087WX20
A0A669KAW3
A0AAQ5BGN3
A0AAQ5BGZ2
H0Y818
P40692
Q59EG3
P09211
V9HWE9
PDB IDs
3RBN
4P7A
5U5P
6WBA
6WBB
6WBC
7M60
10GS
11GS
12GS
13GS
14GS
16GS
17GS
18GS
19GS
1AQV
1AQW
1AQX
1EOG
1EOH
1GSS
1KBN
1LBK
1MD3
1MD4
1PGT
1PX6
1PX7
1ZGN
20GS
22GS
2A2R
2A2S
2GSS
2J9H
2PGT
3CSH
3CSI
3CSJ
3DD3
3DGQ
3GSS
3GUS
3HJM
3HJO
3HKR
3IE3
3KM6
3KMN
3KMO
3N9J
3PGT
4GSS
4PGT
5DAK
5DAL
5DCG
5DDL
5DJL
5DJM
5GSS
5J41
5JCW
5L6X
5X79
6AP9
6GSS
6LLX
6Y1E
7BIA
7GSS
7XBA
8GSS
9GSS
Enriched GO Terms of Interacting Partners
?
Mismatch Repair
Mismatched DNA Binding
ATP-dependent DNA Damage Sensor Activity
Cellular Response To Stress
Apoptotic Signaling Pathway
Response To Estradiol
DNA Damage Response
Dinucleotide Insertion Or Deletion Binding
Intrinsic Apoptotic Signaling Pathway
Response To Corticosteroid
DNA Repair
Mismatch Repair Complex
DNA Metabolic Process
Protein Binding
Response To Glucocorticoid
Damaged DNA Binding
Response To Hydrogen Peroxide
Mitotic DNA Damage Checkpoint Signaling
Nucleic Acid Metabolic Process
Response To Dexamethasone
Mitotic DNA Integrity Checkpoint Signaling
Somatic Cell DNA Recombination
Signal Transduction In Response To DNA Damage
Nucleobase-containing Compound Metabolic Process
Response To Reactive Oxygen Species
MutSbeta Complex
Dinucleotide Repeat Insertion Binding
Response To Steroid Hormone
Nucleus
Response To Stress
Somatic Hypermutation Of Immunoglobulin Genes
DNA Recombination
DNA Damage Checkpoint Signaling
Somatic Recombination Of Immunoglobulin Gene Segments
Fructose-bisphosphate Aldolase Activity
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Single Guanine Insertion Binding
MutLalpha Complex
Response To Oxidative Stress
Cellular Response To Corticosteroid Stimulus
Mucus Secretion
Response To Radiation
Single-stranded DNA Binding
P53 Binding
Response To UV
Mitotic Intra-S DNA Damage Checkpoint Signaling
Signal Sequence Binding
Guanine/thymine Mispair Binding
Satellite DNA Binding
Somatic Diversification Of Immunoglobulins
Keratin Filament
Intermediate Filament
Structural Constituent Of Skin Epidermis
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Structural Molecule Activity
Intermediate Filament-based Process
Protein-glutamine Gamma-glutamyltransferase Activity
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?