MLH1 and EEF1G

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MLH1	EEF1G
Gene Name		mutL homolog 1	eukaryotic translation elongation factor 1 gamma
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Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Nucleus Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	Translation Elongation Factor Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	Translation Translational Elongation Response To Virus Gene Expression Cellular Protein Metabolic Process
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Translation Eukaryotic Translation Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	87 interactors: ABCC9 ADAP2 AKT1 ARF1 ARIH2 C11orf58 C1orf174 CARS CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DRD3 ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EGFR EID2B ENOX1 FAM195A FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS KLHL18 LARS LZTS1 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRS RBM6 RECQL5 RGL2 RPL4P5 RPS28 SAT1 SKIL SNAPIN SNRPD2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 WDR33 YWHAG ZBED8 ZDHHC17 ZNF24
Entrez ID		4292	1937
HPRD ID		00390	11745
Ensembl ID		ENSG00000076242	ENSG00000254772
Uniprot IDs		P40692 Q59EG3	P26641 Q53YD7
PDB IDs		3NA3 3RBN	1PBU
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of Cell Development Chemotaxis Regulation Of Protein Kinase Activity Cell Cycle Regulation Of Endothelial Cell Migration Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Translation Negative Regulation Of Transferase Activity Regulation Of Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Neurogenesis Positive Regulation Of Transferase Activity Regulation Of Intracellular Transport Cellular Response To Mechanical Stimulus Nervous System Development Cellular Response To Growth Factor Stimulus Negative Regulation Of Kinase Activity MRNA Polyadenylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Binding Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process MRNA 3'-end Processing Response To Growth Factor Regulation Of Signal Transduction Mitotic Cell Cycle Immune System Process Regulation Of Cell Projection Organization Response To UV-A Regulation Of Catalytic Activity
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	4egi antiporter antitumoral apparatus atf4 attenuation bip client consequent cyclophilin cystine eef1a eif4a favoring filters gcn2 hsp migrate nascent pores proteostasis ribavirin ribosomes sensitizes sorcin tbp7 transwell trap1 xct
Tagcloud (Intersection) ?