MLH1 and APRT

Number of citations of the paper that reports this interaction (PMID 20706999)
2

Data Source:
BioGRID (two hybrid)

		MLH1	APRT
Gene Name		mutL homolog 1	adenine phosphoribosyltransferase
Image
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	Adenine Binding Adenine Phosphoribosyltransferase Activity AMP Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	Purine Nucleobase Metabolic Process Adenine Salvage Lactation Grooming Behavior Cellular Response To Insulin Stimulus Purine-containing Compound Salvage AMP Salvage Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Purine metabolism Metabolism of nucleotides Purine salvage
Drugs			Adenine Alpha-Phosphoribosylpyrophosphoric Acid 9-Deazaadenine Citric Acid
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	3 interactors: APP IKBKG MLH1
Entrez ID		4292	353
HPRD ID		00390	00029
Ensembl ID		ENSG00000076242	ENSG00000198931
Uniprot IDs		P40692 Q59EG3	P07741
PDB IDs		3NA3 3RBN	1OPU 1ORE 1ZN7 1ZN8 1ZN9
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway MRNA 3'-end Processing RNA 3'-end Processing Apoptotic Process Programmed Cell Death Cell Death Death Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Immune Response Intracellular Receptor Signaling Pathway Negative Regulation Of Mitotic Recombination Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Regulation Of Mitotic Recombination Male Meiosis Chromosome Segregation Establishment Of Organelle Localization Collateral Sprouting Axon Midline Choice Point Recognition Establishment Of Localization In Cell Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Immune System Process Axon Choice Point Recognition Organelle Localization MRNA Processing Spindle Midzone Assembly Cellular Localization Neuron Remodeling Resolution Of Meiotic Recombination Intermediates MRNA Metabolic Process RNA Processing Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Cellular Copper Ion Homeostasis Cell Activation RNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Chromosome Separation Negative Regulation Of DNA Recombination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Kinase Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Isotype Switching Microtubule-based Process Response To Stress Gene Expression Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	62b11 alleles artificial behave breakpoints c1 capped chromosomes cytological deficiencies deleted lambda map maps melanogaster mu2 mutator phage positions potentiates presumptive protected recovered selectable spanning stocks subcloned subclones undiscovered
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	62b11 alleles artificial behave breakpoints c1 capped chromosomes cytological deficiencies deleted lambda map maps melanogaster mu2 mutator phage positions potentiates presumptive protected recovered selectable spanning stocks subcloned subclones undiscovered
Tagcloud (Intersection) ?