MLH3 and MSH5

Number of citations of the paper that reports this interaction (PubMedID 32814904)
0

Data Source:
BioGRID (pull down)

		MLH3	MSH5
Description		mutL homolog 3	mutS homolog 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Nucleus
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization	DNA Repair Mismatch Repair DNA Damage Response Meiosis I Chiasma Assembly Meiotic Cell Cycle
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lung cancer ( 18978787) Mastocytosis ( 32752121) Medication use (anilides) ( 31015401) Menopause (age at onset) ( 26414677) Pulse pressure ( 27618448) Systemic lupus erythematosus ( 26316170) Systemic mastocytosis ( 32752121) Systolic blood pressure ( 27618448) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908 24837172)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	4 interacting genes: MLH1 MLH3 MSH4 TRIM54
Entrez ID		27030	4439
HPRD ID		05094	04544
Ensembl ID		ENSG00000119684	ENSG00000204410
Uniprot IDs		Q2M1Z1 Q9UHC1	A0A024RCM1 O43196
PDB IDs
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Mismatch Repair Reciprocal Meiotic Recombination Chiasma Synaptonemal Complex Condensed Chromosome Homologous Recombination Condensed Nuclear Chromosome Chromosome Organization Involved In Meiotic Cell Cycle Mismatch Repair Complex Homologous Chromosome Pairing At Meiosis DNA Recombination Male Meiotic Nuclear Division Male Germ Cell Nucleus Chromosome Organization Female Gamete Generation Meiosis I Cell Cycle Process Meiotic Nuclear Division Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Recombination Nodule Nuclear Division Reproductive Process DNA Repair Meiotic Cell Cycle Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Alpha-sialidase Activity Male Meiosis Chromosome Segregation MutLalpha Complex DNA Metabolic Process Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Exo-alpha-sialidase Activity Satellite DNA Binding DNA Damage Response Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Luteolysis Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding MutSalpha Complex Binding Regulation Of Mitotic Recombination Positive Regulation Of Transcription Of Notch Receptor Target Female Meiosis I Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Ganglioside Catabolic Process Telomere Localization
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