MLH1 and MSH4

Number of citations: 0 (PubMedID 10928988)
Data Source: HPRD (in vitro, in vivo)

		MLH1	MSH4
Name		mutL homolog 1	mutS homolog 4
Structure			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Chiasma Late Recombination Nodule Membrane Nuclear Lumen Mismatch Repair Complex MutLalpha Complex	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Nucleus Chromosome Recombination Nodule
	Molecular Function	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATP Hydrolysis Activity Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress DNA Damage Response Male Meiosis Chromosome Segregation Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Meiotic Metaphase I Homologous Chromosome Alignment Meiotic Chromosome Segregation Meiotic Telomere Clustering Homologous Chromosome Segregation Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly Meiotic Cell Cycle	Ovarian Follicle Development Mismatch Repair Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation Meiotic Cell Cycle
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination	Meiotic recombination
Diseases		Ovarian cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Colorectal cancer Endometrial Cancer	None
GWAS		Alanine aminotransferase levels ( 33547301 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Platelet distribution width ( 32888494 ) Proximal colorectal cancer ( 33632709 ) Schizophrenia ( 28991256 ) Subjective response to lithium treatment ( 26503763 )	Attention function in attention deficit hyperactive disorder ( 26174813 ) Daytime sleep phenotypes ( 27126917 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Serum metabolite levels ( 23093944 )
Interacting Genes		139 interacting genes: - ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ALDOB ANXA6 AP1B1 AP2B1 APRT ARAF ASS1 ATF2 BAAT BLM BRCA1 BTBD2 C9orf152 CAB39L CAPN5 CASP3 CBY2 CCDC180 CCDC33 CCDC74B CDCA7L CDKL5 CEP126 CEP76 CKAP4 CKB CTSV CYLC2 DDX47 EEF1G EEF2 EIF2A ELP6 ENKD1 EXO1 EXOC3 FAM228A FAM50B FAM90A1 FBXO32 FCGBP FLNB FRAT2 FRMD6 GABARAP GSTP1 HDAC6 IGKC ISY1 KPNA2 KPNA5 KPRP LEF1 LGALS4 LUC7L3 LY96 MAGEA8 MAP2K6 MBD3L1 MBD4 MLH3 MORN3 MPG MSH2 MSH3 MSH4 MSH5 MUC2 MYC MYL6 MYOG NANOS3 NDRG1 NELFA NME4 NT5C3B ORC4 PARP12 PARVA PCNA PER2 PIP4K2B PMS1 PMS2 PPP1R13B PPP2CB PRR5L PSMA1 PTGDS PTPN3 PTPRH RAD23B RAD9A RADX RAPGEFL1 RBM48 RSPH3 SEC61A1 SELENBP1 SERPINF1 SMAD1 SPATA8 SQSTM1 STAP2 STX17 SYF2 TASOR2 TDRD7 TFAP2D TLE5 TRIM23 TRIM29 TRMO TSGA13 TXN TXN2 U2AF1 UBOX5 VAMP8 XPA ZBED1 ZC3H11A ZER1 ZFP57 ZFP90 ZMAT5 ZNF177 ZNF212 ZNF474 ZNF559-ZNF177 ZNF774	9 interacting genes: CFTR DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1
Entrez ID		4292	4438
HPRD ID		00390	03658
Ensembl ID		ENSG00000076242	ENSG00000057468
Uniprot IDs		A0A087WX20 A0A669KAW3 A0AAQ5BGN3 A0AAQ5BGZ2 H0Y818 P40692 Q59EG3	O15457
PDB IDs		3RBN 4P7A 5U5P 6WBA 6WBB 6WBC 7M60	Not available
GO Terms Enriched among Interactors		Mismatch Repair Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Cellular Response To Stress Apoptotic Signaling Pathway Response To Estradiol DNA Damage Response Dinucleotide Insertion Or Deletion Binding Intrinsic Apoptotic Signaling Pathway Response To Corticosteroid DNA Repair Mismatch Repair Complex DNA Metabolic Process Protein Binding Response To Glucocorticoid Damaged DNA Binding Response To Hydrogen Peroxide Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Response To Dexamethasone Mitotic DNA Integrity Checkpoint Signaling Somatic Cell DNA Recombination Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Response To Reactive Oxygen Species MutSbeta Complex Dinucleotide Repeat Insertion Binding Response To Steroid Hormone Nucleus Response To Stress Somatic Hypermutation Of Immunoglobulin Genes DNA Recombination DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Fructose-bisphosphate Aldolase Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Single Guanine Insertion Binding MutLalpha Complex Response To Oxidative Stress Cellular Response To Corticosteroid Stimulus Mucus Secretion Response To Radiation Single-stranded DNA Binding P53 Binding Response To UV Mitotic Intra-S DNA Damage Checkpoint Signaling Signal Sequence Binding Guanine/thymine Mispair Binding Satellite DNA Binding Somatic Diversification Of Immunoglobulins	ATP-dependent DNA Damage Sensor Activity Condensed Nuclear Chromosome Meiosis I Cell Cycle Process Meiotic Nuclear Division Nuclear Division Reciprocal Meiotic Recombination Mismatch Repair Condensed Chromosome Meiotic Cell Cycle Homologous Recombination Meiosis I Male Germ Cell Nucleus Chromosome Organization Involved In Meiotic Cell Cycle Mismatched DNA Binding Lateral Element DNA Recombination DNA Repair Chiasma DNA Strand Exchange Activity Single-stranded DNA Binding Chromosome Organization DNA Metabolic Process DNA Damage Response Reproductive Process Male Meiotic Nuclear Division Mismatch Repair Complex DNA Strand Invasion DNA Recombinase Assembly Cellular Response To Stress Double-strand Break Repair Double-strand Break Repair Involved In Meiotic Recombination Site Of Double-strand Break Response To Stress ATP Binding Double-stranded DNA Binding Mitotic Recombination Double-strand Break Repair Via Homologous Recombination Recombinational Repair Synaptonemal Complex Cellular Component Assembly Homologous Chromosome Pairing At Meiosis Chromatin Binding Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome ATP-dependent Activity, Acting On DNA Oogenesis Nucleic Acid Metabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity