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MLH1 and TLE5
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
MLH1
TLE5
Description
mutL homolog 1
TLE family member 5, transcriptional modulator
Image
No pdb structure
GO Annotations
Cellular Component
Condensed Chromosome
Condensed Nuclear Chromosome
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Chiasma
Late Recombination Nodule
Membrane
Nuclear Lumen
Mismatch Repair Complex
MutLalpha Complex
Nucleus
Molecular Function
Nucleotide Binding
Chromatin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP Hydrolysis Activity
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
ATP-dependent DNA Damage Sensor Activity
Transcription Corepressor Activity
Protein Binding
Identical Protein Binding
Biological Process
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response
DNA Repair
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Response To Stress
DNA Damage Response
Male Meiosis Chromosome Segregation
Homologous Chromosome Pairing At Meiosis
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Bacterium
Female Meiosis Chromosome Segregation
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
Meiotic Metaphase I Homologous Chromosome Alignment
Meiotic Chromosome Segregation
Meiotic Telomere Clustering
Homologous Chromosome Segregation
Isotype Switching
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Oogenesis
Meiotic Spindle Midzone Assembly
Meiotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Regulation Of Growth
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Response To Cytokine Stimulus
Response To Interleukin-1
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Anoikis
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
TP53 Regulates Transcription of DNA Repair Genes
Meiotic recombination
Repression of WNT target genes
Drugs
Diseases
Ovarian cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Colorectal cancer
Endometrial Cancer
GWAS
Alanine aminotransferase levels (
33547301
)
Autism spectrum disorder or schizophrenia (
28540026
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Platelet distribution width (
32888494
)
Proximal colorectal cancer (
33632709
)
Schizophrenia (
28991256
)
Subjective response to lithium treatment (
26503763
)
Interacting Genes
139 interacting genes:
-
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ALDOB
ANXA6
AP1B1
AP2B1
APRT
ARAF
ASS1
ATF2
BAAT
BLM
BRCA1
BTBD2
C9orf152
CAB39L
CAPN5
CASP3
CBY2
CCDC180
CCDC33
CCDC74B
CDCA7L
CDKL5
CEP126
CEP76
CKAP4
CKB
CTSV
CYLC2
DDX47
EEF1G
EEF2
EIF2A
ELP6
ENKD1
EXO1
EXOC3
FAM228A
FAM50B
FAM90A1
FBXO32
FCGBP
FLNB
FRAT2
FRMD6
GABARAP
GSTP1
HDAC6
IGKC
ISY1
KPNA2
KPNA5
KPRP
LEF1
LGALS4
LUC7L3
LY96
MAGEA8
MAP2K6
MBD3L1
MBD4
MLH3
MORN3
MPG
MSH2
MSH3
MSH4
MSH5
MUC2
MYC
MYL6
MYOG
NANOS3
NDRG1
NELFA
NME4
NT5C3B
ORC4
PARP12
PARVA
PCNA
PER2
PIP4K2B
PMS1
PMS2
PPP1R13B
PPP2CB
PRR5L
PSMA1
PTGDS
PTPN3
PTPRH
RAD23B
RAD9A
RADX
RAPGEFL1
RBM48
RSPH3
SEC61A1
SELENBP1
SERPINF1
SMAD1
SPATA8
SQSTM1
STAP2
STX17
SYF2
TASOR2
TDRD7
TFAP2D
TLE5
TRIM23
TRIM29
TRMO
TSGA13
TXN
TXN2
U2AF1
UBOX5
VAMP8
XPA
ZBED1
ZC3H11A
ZER1
ZFP57
ZFP90
ZMAT5
ZNF177
ZNF212
ZNF474
ZNF559-ZNF177
ZNF774
363 interacting genes:
ABI2
ACTMAP
AEN
AGR2
AIRIM
AKAP8L
ANAPC11
ANKRD11
AR
ARHGAP32
ARX
ASB3
ATN1
ATOSB
ATP6V0D1
BAG4
BAHD1
BCL6
BHLHE40
BIRC7
BPIFA1
BYSL
C10orf55
C14orf119
C1orf216
C1orf94
C7orf57
CABP2
CABP4
CABP5
CALCOCO2
CAPN1
CARD9
CATSPERT
CCDC120
CCDC57
CCL7
CCNJL
CCNK
CFAP206
CFAP68
CIB3
CLIC3
CLIP3
CNFN
COA7
CPSF7
CRACR2A
CSNK1E
CSNK2A1
CSTF2
CSTF2T
CT55
CTBP2
CYSRT1
DAZAP2
DCUN1D1
DDX6
DGCR6
DIP2A
DMRT2
DMRT3
DMRTB1
DNMT3L
DOK6
DVL2
DVL3
DYDC1
EAF1
EAF2
EFEMP2
EFHC1
EIF1AD
EIF4E2
ERF
EXOSC5
EYA2
FAM124A
FAM124B
FAM168B
FAM217B
FAM90A1
FANCG
FBF1
FCHSD2
FHL3
FOSB
FOXD2
FOXN1
FOXP2
FRS3
FSD2
FXR1
FXR2
GABARAP
GATA1
GCC1
GEM
GFAP
GFI1B
GIGYF1
GLIS2
GLRX3
GOLGA2
GOLGA6L9
GORASP2
GPANK1
GPATCH2L
GRAP2
GRB2
GRN
GTF2E1
GYS1
HDAC4
HDHD3
HELT
HEXIM2
HGS
HHEX
HMGB1
HNF1A
HNRNPF
HNRNPH2
HNRNPK
HNRNPLL
HOMEZ
HOXA1
HOXB5
HOXC8
HOXC9
IKZF3
INO80B
INO80E
INPP5J
IRX2
IRX6
KANK2
KDM1A
KIFC3
KLF1
KLF4
KLHDC7B
KRT13
KRT15
KRT31
KRT34
KRT35
KRT40
KRTAP1-1
KRTAP10-11
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-5
KRTAP19-7
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
L3MBTL2
LDLR
LDOC1
LENG8
LINC00526
LMO1
LMO2
LMO4
LSM2
LZTS2
MAGOHB
MAPK1
MAPK14
MAPRE3
MBNL1
MCRS1
MDFI
MECOM
MED12L
MED25
MED31
MED4
MEIS3
MFAP1
MIA2
MIIP
MKRN3
MLH1
MLLT6
MLX
MORF4L1
MORF4L2
MSS51
MSX1
MSX2
MTUS2
MVP
MYF5
MYH7B
MYO15B
MYOG
NAB2
NAF1
NBPF19
NCDN
NDOR1
NDUFB7
NEK6
NLGN3
NOTCH2NLA
NTAQ1
NUDT22
NUTF2
NUTM1
OLIG3
OSGIN1
OXER1
P4HA3
PARVG
PATZ1
PCBP1
PCSK5
PFDN5
PHF1
PICK1
PITX1
PITX2
PLAGL1
POLR1C
POU2F1
PPP1R16A
PPP1R16B
PRDM1
PRDM14
PRDM6
PRKAA1
PRKAA2
PRKAB2
PROP1
PRPF31
PRR3
PRR35
PSMB1
PSMB4
PSMF1
PTRH2
QARS1
RAD51D
RBM10
RBPMS
REL
RELA
RFX6
RHOXF2
RIBC1
RIMBP3
RNF31
RORB
RPL18A
RUNX1
RUSC1
SAT1
SCNM1
SDCBP
SERTAD3
SET
SF3B4
SH2B2
SH3GL3
SHFL
SHISA6
SIX1
SIX2
SIX3
SIX6
SKIL
SKP2
SMAD3
SMAD4
SMARCB1
SMARCD1
SNCAIP
SNRPA
SNRPC
SOHLH1
SPATA25
SPG21
SPMIP9
SRPK2
SSC4D
STK16
STX11
SUFU
SUPT5H
TBX3
TBX6
TCEANC
TCF4
TCF7L2
TEAD4
TENT5B
TFAP2D
THAP7
TIGD3
TMCC2
TNS2
TOX3
TRAF1
TRAF2
TRIB3
TRIM26
TRIM27
TRIM41
TRIP6
TRMT2A
TSC1
TSC22D4
TSEN15
TSGA10
TSGA10IP
TSSK3
TTC23
U2AF2
UBAP2
UBE2H
UBL5
UBXN11
USP2
USP54
VEZF1
VGLL1
VIM
VPS37B
VPS37C
YPEL3
YTHDF1
ZBTB16
ZBTB24
ZBTB47
ZFHX3
ZGPAT
ZIC1
ZMYND12
ZNF330
ZNF34
ZNF383
ZNF408
ZNF414
ZNF417
ZNF467
ZNF48
ZNF503
ZNF524
ZNF576
ZNF688
ZNF792
ZNF835
ZRANB1
Entrez ID
4292
166
HPRD ID
00390
02556
Ensembl ID
ENSG00000076242
ENSG00000104964
Uniprot IDs
A0A087WX20
A0A669KAW3
A0AAQ5BGN3
A0AAQ5BGZ2
H0Y818
P40692
Q59EG3
Q08117
PDB IDs
3RBN
4P7A
5U5P
6WBA
6WBB
6WBC
7M60
Enriched GO Terms of Interacting Partners
?
Mismatch Repair
Mismatched DNA Binding
ATP-dependent DNA Damage Sensor Activity
Cellular Response To Stress
Apoptotic Signaling Pathway
Response To Estradiol
DNA Damage Response
Dinucleotide Insertion Or Deletion Binding
Intrinsic Apoptotic Signaling Pathway
Response To Corticosteroid
DNA Repair
Mismatch Repair Complex
DNA Metabolic Process
Protein Binding
Response To Glucocorticoid
Damaged DNA Binding
Response To Hydrogen Peroxide
Mitotic DNA Damage Checkpoint Signaling
Nucleic Acid Metabolic Process
Response To Dexamethasone
Mitotic DNA Integrity Checkpoint Signaling
Somatic Cell DNA Recombination
Signal Transduction In Response To DNA Damage
Nucleobase-containing Compound Metabolic Process
Response To Reactive Oxygen Species
MutSbeta Complex
Dinucleotide Repeat Insertion Binding
Response To Steroid Hormone
Nucleus
Response To Stress
Somatic Hypermutation Of Immunoglobulin Genes
DNA Recombination
DNA Damage Checkpoint Signaling
Somatic Recombination Of Immunoglobulin Gene Segments
Fructose-bisphosphate Aldolase Activity
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Single Guanine Insertion Binding
MutLalpha Complex
Response To Oxidative Stress
Cellular Response To Corticosteroid Stimulus
Mucus Secretion
Response To Radiation
Single-stranded DNA Binding
P53 Binding
Response To UV
Mitotic Intra-S DNA Damage Checkpoint Signaling
Signal Sequence Binding
Guanine/thymine Mispair Binding
Satellite DNA Binding
Somatic Diversification Of Immunoglobulins
Protein Binding
Regulation Of RNA Metabolic Process
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
Positive Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Intermediate Filament
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA Binding
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Sequence-specific DNA Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Sequence-specific Double-stranded DNA Binding
Negative Regulation Of Metabolic Process
Keratin Filament
Identical Protein Binding
Transcription Cis-regulatory Region Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Cellular Developmental Process
Cell Differentiation
Pattern Specification Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Tagcloud
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Tagcloud (Intersection)
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