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MLH1 and ORC4
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
MLH1
ORC4
Description
mutL homolog 1
origin recognition complex subunit 4
Image
GO Annotations
Cellular Component
Condensed Chromosome
Condensed Nuclear Chromosome
Synaptonemal Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Chiasma
Late Recombination Nodule
Membrane
Nuclear Lumen
Mismatch Repair Complex
MutLalpha Complex
Chromosome, Telomeric Region
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Nucleolus
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Chromatin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP Hydrolysis Activity
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
MutSalpha Complex Binding
ATP-dependent DNA Damage Sensor Activity
Nucleotide Binding
DNA Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Biological Process
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Resolution Of Meiotic Recombination Intermediates
Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response
DNA Repair
Mismatch Repair
Double-strand Break Repair Via Nonhomologous End Joining
Response To Stress
DNA Damage Response
Male Meiosis Chromosome Segregation
Homologous Chromosome Pairing At Meiosis
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Bacterium
Female Meiosis Chromosome Segregation
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
Meiotic Metaphase I Homologous Chromosome Alignment
Meiotic Chromosome Segregation
Meiotic Telomere Clustering
Homologous Chromosome Segregation
Isotype Switching
Negative Regulation Of Mitotic Recombination
Positive Regulation Of Isotype Switching To IgA Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Oogenesis
Meiotic Spindle Midzone Assembly
Meiotic Cell Cycle
DNA Replication
DNA Replication Initiation
Polar Body Extrusion After Meiotic Divisions
Protein Polymerization
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Defective Mismatch Repair Associated With MLH1
Defective Mismatch Repair Associated With PMS2
TP53 Regulates Transcription of DNA Repair Genes
Meiotic recombination
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Drugs
Diseases
Ovarian cancer
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Colorectal cancer
Endometrial Cancer
Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS
Alanine aminotransferase levels (
33547301
)
Autism spectrum disorder or schizophrenia (
28540026
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Platelet distribution width (
32888494
)
Proximal colorectal cancer (
33632709
)
Schizophrenia (
28991256
)
Subjective response to lithium treatment (
26503763
)
Estimated glomerular filtration rate (
30604766
31015462
31152163
)
Loneliness (MTAG) (
29970889
)
Serum uric acid levels (
30993211
)
Urate levels (
31578528
)
Interacting Genes
139 interacting genes:
-
ABCC3
ABHD16A
ACER3
ACTG2
AGR2
AIFM1
ALDOA
ALDOB
ANXA6
AP1B1
AP2B1
APRT
ARAF
ASS1
ATF2
BAAT
BLM
BRCA1
BTBD2
C9orf152
CAB39L
CAPN5
CASP3
CBY2
CCDC180
CCDC33
CCDC74B
CDCA7L
CDKL5
CEP126
CEP76
CKAP4
CKB
CTSV
CYLC2
DDX47
EEF1G
EEF2
EIF2A
ELP6
ENKD1
EXO1
EXOC3
FAM228A
FAM50B
FAM90A1
FBXO32
FCGBP
FLNB
FRAT2
FRMD6
GABARAP
GSTP1
HDAC6
IGKC
ISY1
KPNA2
KPNA5
KPRP
LEF1
LGALS4
LUC7L3
LY96
MAGEA8
MAP2K6
MBD3L1
MBD4
MLH3
MORN3
MPG
MSH2
MSH3
MSH4
MSH5
MUC2
MYC
MYL6
MYOG
NANOS3
NDRG1
NELFA
NME4
NT5C3B
ORC4
PARP12
PARVA
PCNA
PER2
PIP4K2B
PMS1
PMS2
PPP1R13B
PPP2CB
PRR5L
PSMA1
PTGDS
PTPN3
PTPRH
RAD23B
RAD9A
RADX
RAPGEFL1
RBM48
RSPH3
SEC61A1
SELENBP1
SERPINF1
SMAD1
SPATA8
SQSTM1
STAP2
STX17
SYF2
TASOR2
TDRD7
TFAP2D
TLE5
TRIM23
TRIM29
TRMO
TSGA13
TXN
TXN2
U2AF1
UBOX5
VAMP8
XPA
ZBED1
ZC3H11A
ZER1
ZFP57
ZFP90
ZMAT5
ZNF177
ZNF212
ZNF474
ZNF559-ZNF177
ZNF774
28 interacting genes:
APP
CCND1
CDKN2A
CTBP1
FBXL5
FBXL8
FBXO25
FBXO6
H3-4
H4C16
KLHL20
KPNA1
MCM10
MCM2
MCM3
MCM4
MCM6
MCM7
MLH1
MTUS1
ORC1
ORC2
ORC3
ORC5
ORC6
RDH5
RRM2B
TCF4
Entrez ID
4292
5000
HPRD ID
00390
09118
Ensembl ID
ENSG00000076242
ENSG00000115947
Uniprot IDs
A0A087WX20
A0A669KAW3
A0AAQ5BGN3
A0AAQ5BGZ2
H0Y818
P40692
Q59EG3
A8K7H4
O43929
Q96B14
PDB IDs
3RBN
4P7A
5U5P
6WBA
6WBB
6WBC
7M60
5UJ7
5UJM
7CTE
7CTF
7CTG
7JPO
7JPP
7JPQ
7JPR
7JPS
8RWV
8S0C
8S0D
8S0E
8S0F
Enriched GO Terms of Interacting Partners
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Mismatch Repair
Mismatched DNA Binding
ATP-dependent DNA Damage Sensor Activity
Cellular Response To Stress
Apoptotic Signaling Pathway
Response To Estradiol
DNA Damage Response
Dinucleotide Insertion Or Deletion Binding
Intrinsic Apoptotic Signaling Pathway
Response To Corticosteroid
DNA Repair
Mismatch Repair Complex
DNA Metabolic Process
Protein Binding
Response To Glucocorticoid
Damaged DNA Binding
Response To Hydrogen Peroxide
Mitotic DNA Damage Checkpoint Signaling
Nucleic Acid Metabolic Process
Response To Dexamethasone
Mitotic DNA Integrity Checkpoint Signaling
Somatic Cell DNA Recombination
Signal Transduction In Response To DNA Damage
Nucleobase-containing Compound Metabolic Process
Response To Reactive Oxygen Species
MutSbeta Complex
Dinucleotide Repeat Insertion Binding
Response To Steroid Hormone
Nucleus
Response To Stress
Somatic Hypermutation Of Immunoglobulin Genes
DNA Recombination
DNA Damage Checkpoint Signaling
Somatic Recombination Of Immunoglobulin Gene Segments
Fructose-bisphosphate Aldolase Activity
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Single Guanine Insertion Binding
MutLalpha Complex
Response To Oxidative Stress
Cellular Response To Corticosteroid Stimulus
Mucus Secretion
Response To Radiation
Single-stranded DNA Binding
P53 Binding
Response To UV
Mitotic Intra-S DNA Damage Checkpoint Signaling
Signal Sequence Binding
Guanine/thymine Mispair Binding
Satellite DNA Binding
Somatic Diversification Of Immunoglobulins
DNA Replication Initiation
DNA Replication
Nuclear Origin Of Replication Recognition Complex
Chromosome, Telomeric Region
Origin Recognition Complex
DNA Replication Origin Binding
DNA Metabolic Process
CMG Complex
MCM Complex
Double-strand Break Repair Via Break-induced Replication
Regulation Of DNA-templated DNA Replication Initiation
Single-stranded DNA Binding
Regulation Of DNA Replication
Nucleus
Mitotic DNA Replication Initiation
Single-stranded DNA Helicase Activity
Regulation Of DNA Metabolic Process
Chromosome
Nucleic Acid Metabolic Process
DNA Damage Response
DNA Helicase Activity
Nucleoplasm
DNA Repair
DNA Binding
Double-strand Break Repair
DNA Strand Elongation Involved In DNA Replication
ATP Hydrolysis Activity
Nucleobase-containing Compound Metabolic Process
Helicase Activity
DNA Recombination
Double-strand Break Repair Via Homologous Recombination
Macromolecule Metabolic Process
Recombinational Repair
DNA Strand Elongation
Cellular Response To Stress
DNA-templated DNA Replication
SCF Ubiquitin Ligase Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Protein-DNA Complex Assembly
Mammary Gland Epithelial Cell Proliferation
Regulation Of Mammary Gland Epithelial Cell Proliferation
Enzyme Binding
Nucleolus
Regulation Of Cell Cycle Phase Transition
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Nucleosome Assembly
Cell Population Proliferation
Regulation Of Cell Cycle G2/M Phase Transition
Amyloid Fibril Formation
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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