MLH1 and MBD4

Number of citations of the paper that reports this interaction (PMID 10097147)
53

Data Source:
HPRD (two hybrid, in vivo)

		MLH1	MBD4
Gene Name		mutL homolog 1	methyl-CpG binding domain protein 4
Image
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Membrane MutLalpha Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Guanine/thymine Mispair Binding MutSalpha Complex Binding	Satellite DNA Binding Endodeoxyribonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates DNA Repair Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Isotype Switching Negative Regulation Of Mitotic Recombination Oogenesis Meiotic Spindle Midzone Assembly	DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Mitotic G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Depyrimidination
Pathways		Meiotic recombination Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair	Base Excision Repair Depyrimidination Resolution of AP sites via the multiple-nucleotide patch replacement pathway Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected pyrimidine Removal of DNA patch containing abasic residue Base-Excision Repair, AP Site Formation Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-Protein Interactions		74 interactors: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CKAP4 CKB CXorf57 DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GSTP1 IGKC KPNA2 LGALS4 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SPERT SQSTM1 STAP2 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZC3H11A ZER1	12 interactors: CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 SIN3A SUV39H1 TRIM27 UHRF1
Entrez ID		4292	8930
HPRD ID		00390	04654
Ensembl ID		ENSG00000076242	ENSG00000129071
Uniprot IDs		P40692 Q59EG3	E9PEE4 O95243
PDB IDs		3NA3 3RBN	3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Response To Stimulus Response To Stimulus Mismatch Repair Response To Stress DNA Metabolic Process DNA Catabolic Process DNA Recombination Negative Regulation Of Cell Cycle DNA Repair Cell Cycle Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance DNA Damage Checkpoint Mitotic DNA Damage Checkpoint Mucus Secretion Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Nucleic Acid Phosphodiester Bond Hydrolysis Cell Death Death Response To Abiotic Stimulus Cell Cycle Checkpoint Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Dexamethasone Stimulus Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Dexamethasone Homeostatic Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Catabolic Process, Exonucleolytic Somatic Recombination Of Immunoglobulin Gene Segments G2 DNA Damage Checkpoint DNA Catabolic Process, Endonucleolytic Regulation Of Apoptotic DNA Fragmentation Somatic Diversification Of Immunoglobulins Reciprocal Meiotic Recombination Anatomical Structure Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Actin-mediated Cell Contraction	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Chromosome Organization Chromatin Modification Motor Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Histone Modification Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Necroptotic Signaling Pathway Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of DNA Binding Negative Regulation Of Chromosome Organization Rhythmic Process Positive Regulation Of Protein Metabolic Process Immune System Development DNA Methylation On Cytosine Negative Regulation Of Histone H3-K9 Methylation Cell Cycle Negative Regulation Of Circadian Rhythm Regulation Of Histone Modification Negative Regulation Of Histone Methylation Positive Regulation Of Gene Expression Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Transcription Negative Regulation Of Programmed Cell Death Gene Expression Regulation Of Histone H3-K4 Methylation Response To Stimulus Negative Regulation Of Cell Death Regulation Of Myeloid Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus
Tagcloud ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	aa aetiology alopecia anagen areata ccl5 dnmt1 ehmt2 ep300 g9a hair hdac2 hdac7 jarid1a jmjd2a jmjd2b jmjd2c kdm1a kdm4a kdm4b kdm4c kdm5a lsd1 mbd1 methylcytosine pbmcs rantes set7 setd7
Tagcloud (Difference) ?		9p24 actionable arid1a atlas barr bystander cd274 cdkn2a classifier comes comprises cpg ebv enrollment epstein fail gastrogenus genomically harbor innocent instability intimately l2 lytic microsatellite msi noncoding pdcd1lg2 qualify	aa aetiology alopecia anagen areata ccl5 dnmt1 ehmt2 ep300 g9a hair hdac2 hdac7 jarid1a jmjd2a jmjd2b jmjd2c kdm1a kdm4a kdm4b kdm4c kdm5a lsd1 mbd1 methylcytosine pbmcs rantes set7 setd7
Tagcloud (Intersection) ?