MLH3 and TMEFF1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		MLH3	TMEFF1
Description		mutL homolog 3	transmembrane protein with EGF like and two follistatin like domains 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Plasma Membrane Membrane
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Receptor Ligand Inhibitor Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization	Host-mediated Suppression Of Symbiont Invasion Symbiont Entry Into Host Cell
Pathways		Meiotic recombination
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Aspartate aminotransferase levels ( 33547301) Familial squamous cell lung carcinoma ( 29924316)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	10 interacting genes: APC BUB1 CCR1 CDKN2A DLC1 DYRK1A FLCN MLH3 PTEN PTPRJ
Entrez ID		27030	8577
HPRD ID		05094	04570
Ensembl ID		ENSG00000119684	ENSG00000241697
Uniprot IDs		Q2M1Z1 Q9UHC1	Q8IYR6
PDB IDs
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cellular Component Organization Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell-matrix Adhesion Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-substrate Adhesion Regulation Of Cellular Component Organization Negative Regulation Of Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Junction Assembly Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Regulation Of Protein Modification Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Ruffle Membrane Beta-catenin Binding Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Negative Regulation Of Focal Adhesion Assembly Regulation Of Phosphorylation Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Catalytic Activity Cell Junction Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Migration
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