MLH3 and CCDC180

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		MLH3	CCDC180
Description		mutL homolog 3	coiled-coil domain containing 180
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Extracellular Exosome
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization
Pathways		Meiotic recombination
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	21 interacting genes: BCL10 BUB1 CDKN2A CTNNA1 DLC1 ERBB2 FLCN MCC MECOM MLH1 MLH3 MSH2 NRAS PDGFRL PMS2 PTEN PTPN12 RB1 SMAD4 SRC STK11
Entrez ID		27030	100499483
HPRD ID		05094
Ensembl ID		ENSG00000119684	ENSG00000197816
Uniprot IDs		Q2M1Z1 Q9UHC1	A0A6E1Y6F7 B4DZK1 Q9P1Z9
PDB IDs
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Intracellular Signal Transduction Mismatched DNA Binding Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation ATP-dependent DNA Damage Sensor Activity Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Mismatch Repair Signal Transduction Negative Regulation Of Cell-matrix Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Somatic Hypermutation Of Immunoglobulin Genes Nucleus Somatic Diversification Of Immune Receptors Via Somatic Mutation Regulation Of Multicellular Organismal Process Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Protein Localization To Nucleus Cell Population Proliferation Chiasma Negative Regulation Of Focal Adhesion Assembly Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Nucleoplasm Cytosol Intracellular Signaling Cassette MutLalpha Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Developmental Process Regulation Of Protein Phosphorylation Positive Regulation Of Isotype Switching Apoptotic Process Negative Regulation Of Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Regulation Of Cell Activation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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