MLH3 and AOPEP

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		MLH3	AOPEP
Description		mutL homolog 3	aminopeptidase O (putative)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Nucleus Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Aminopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization	Proteolysis
Pathways		Meiotic recombination
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)	Hodgkin's lymphoma ( 34216518)
Interacting Genes		48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510	9 interacting genes: BMPR1A BUB1 CDH1 CDKN2A DLC1 EGFR MLH3 NRAS SMAD4
Entrez ID		27030	84909
HPRD ID		05094	07476
Ensembl ID		ENSG00000119684	ENSG00000148120
Uniprot IDs		Q2M1Z1 Q9UHC1	Q8N6M6
PDB IDs
Enriched GO Terms of Interacting Partners?		Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration	Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Mesendoderm Development Regulation Of Transforming Growth Factor Beta2 Production Regulation Of MiRNA Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cardiocyte Differentiation Cardiac Conduction System Development Regulation Of Epithelial Cell Proliferation Regulation Of Cell Growth Regulation Of Cellular Component Organization Epithelial Cell Proliferation Outflow Tract Septum Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Developmental Process Cellular Response To BMP Stimulus Pituitary Gland Development Negative Regulation Of Cell Growth Animal Organ Morphogenesis Endoderm Development Positive Regulation Of Epithelial Cell Proliferation Intracellular Signal Transduction Negative Regulation Of Cell-matrix Adhesion Ventricular Septum Morphogenesis Negative Regulation Of Growth Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process MAPK Cascade Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Neural Crest Cell Differentiation Embryonic Digit Morphogenesis Gland Development SMAD Binding Cellular Response To Growth Factor Stimulus Tube Morphogenesis Neural Plate Mediolateral Regionalization Paraxial Mesoderm Structural Organization Regulation Of Cardiac Muscle Cell Apoptotic Process Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cell Development Cell Population Proliferation Tissue Development Fibrous Ring Of Heart Morphogenesis Mesoderm Development Positive Regulation Of Cardiac Ventricle Development Negative Regulation Of Cellular Component Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
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