ECE1 and MTNR1A

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		ECE1	MTNR1A
Description		endothelin converting enzyme 1	melatonin receptor 1A
Image
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Signal Transduction G Protein-coupled Receptor Signaling Pathway Axon Guidance Heart Development Anatomical Structure Morphogenesis Gene Expression Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Neuron Projection Development Endothelin Maturation Embryonic Heart Tube Development Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development Axonogenesis Involved In Innervation Sympathetic Neuron Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm
Pathways		Peptide ligand-binding receptors	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		5-(2-hydroxyethyl)nonane-1,9-diol	Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Feeling worry ( 29500382) Height ( 25282103) Longevity (age >90th survival percentile) ( 31413261) Morning person ( 30696823) Obesity-related traits ( 23251661) Weight ( 28552196)	Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)
Interacting Genes		14 interacting genes: AGT CALCA CLK1 CLK2 CYSRT1 EDN1 KNG1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-8 MTDH MTNR1A MYOC	160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460
Entrez ID		1889	4543
HPRD ID		02690	02812
Ensembl ID		ENSG00000117298	ENSG00000168412
Uniprot IDs		P42892	P48039
PDB IDs		3DWB	6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
Enriched GO Terms of Interacting Partners?		Keratin Filament Hormone Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Intermediate Filament Skeletal Muscle Adaptation Regulation Of Renal Sodium Excretion Vascular Process In Circulatory System Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Renal Sodium Ion Transport Receptor Ligand Activity Renal Sodium Ion Absorption Circulatory System Process Positive Regulation Of Extracellular Matrix Organization Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Vasoconstriction Regulation Of Blood Pressure Positive Regulation Of Cardiac Muscle Hypertrophy Response To Testosterone Renal Absorption Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Response To Dexamethasone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endothelin A Receptor Binding Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Rhythmic Excitation Skeletal Muscle Hypertrophy G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of Coagulation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Muscle Cell Apoptotic Process Cellular Response To Glucocorticoid Stimulus Regulation Of Muscle System Process Regulation Of Smooth Muscle Contraction Muscle System Process Regulation Of Extracellular Matrix Organization Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Membrane Hyperpolarization Negative Regulation Of Cation Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Type 2 Angiotensin Receptor Binding Regulation Of Monoatomic Cation Transmembrane Transport	Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity
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