ECE1 and CLK1

Number of citations of the paper that reports this interaction (PubMedID 26167880)
0

Data Source:
BioGRID (enzymatic study)

		ECE1	CLK1
Description		endothelin converting enzyme 1	CDC like kinase 1
Image
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Signal Transduction G Protein-coupled Receptor Signaling Pathway Axon Guidance Heart Development Anatomical Structure Morphogenesis Gene Expression Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Neuron Projection Development Endothelin Maturation Embryonic Heart Tube Development Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development Axonogenesis Involved In Innervation Sympathetic Neuron Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Regulation Of RNA Splicing
Pathways		Peptide ligand-binding receptors
Drugs		5-(2-hydroxyethyl)nonane-1,9-diol	Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Feeling worry ( 29500382) Height ( 25282103) Longevity (age >90th survival percentile) ( 31413261) Morning person ( 30696823) Obesity-related traits ( 23251661) Weight ( 28552196)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		14 interacting genes: AGT CALCA CLK1 CLK2 CYSRT1 EDN1 KNG1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-8 MTDH MTNR1A MYOC	170 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP CLK2 COCH CRNKL1 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DDX23 DENND4A DNAJC13 DNAJC24 DOCK9 DPYD DSC2 DVL3 ECE1 ELP6 ENO1 ENTREP2 ERFE FAT1 FBF1 FHIP2B GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-6 KRTAP10-7 LINS1 LMNA LNX1 LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MICU3 MKRN2 MTBP MTCL1 MTPAP MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIGP PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRP4K PRPF38A PRPF4 PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SH2B2 SHROOM1 SLC35D3 SLC75A1 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRRM4 SRSF1 SRSF10 SRSF12 SRSF6 SRSF8 SSBP3 STIP1 STK31 SVOP TDRD9 TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148 ZNF830 ZRSR2
Entrez ID		1889	1195
HPRD ID		02690	09058
Ensembl ID		ENSG00000117298	ENSG00000013441
Uniprot IDs		P42892	P49759
PDB IDs		3DWB	1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6QTY 6R3D 6R6E 6R6X 6R8J 6RAA 6TW2 6YTA 6YTD 6YTE 6YTG 6YTI 6Z4Z 6Z50 6ZLN 7AK3 7O9Y 7OA0 7OPG 8P04 8P08 8UWN
Enriched GO Terms of Interacting Partners?		Keratin Filament Hormone Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Intermediate Filament Skeletal Muscle Adaptation Regulation Of Renal Sodium Excretion Vascular Process In Circulatory System Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Renal Sodium Ion Transport Receptor Ligand Activity Renal Sodium Ion Absorption Circulatory System Process Positive Regulation Of Extracellular Matrix Organization Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Vasoconstriction Regulation Of Blood Pressure Positive Regulation Of Cardiac Muscle Hypertrophy Response To Testosterone Renal Absorption Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Response To Dexamethasone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endothelin A Receptor Binding Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Rhythmic Excitation Skeletal Muscle Hypertrophy G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of Coagulation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Muscle Cell Apoptotic Process Cellular Response To Glucocorticoid Stimulus Regulation Of Muscle System Process Regulation Of Smooth Muscle Contraction Muscle System Process Regulation Of Extracellular Matrix Organization Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Membrane Hyperpolarization Negative Regulation Of Cation Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Type 2 Angiotensin Receptor Binding Regulation Of Monoatomic Cation Transmembrane Transport	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing RNA Metabolic Process RNA Binding Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Catalytic Step 2 Spliceosome Nucleoplasm Nucleic Acid Binding MRNA Splice Site Recognition Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Negative Regulation Of RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RS Domain Binding Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Nuclear Matrix Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Topoisomerase Binding
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