ECE1 and CLK2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ECE1	CLK2
Gene Name		endothelin converting enzyme 1	CDC-like kinase 2
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Endosome Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Heart Development Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Endothelin Maturation Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Response To Retinoic Acid Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: AGT CALCA CLK2 EDN1 KNG1 KRTAP10-1 KRTAP10-5 MYOC	30 interactors: AKT1 CLK3 CPSF7 ECE1 GMCL1 KLHL2 LNX1 LUZP4 MRPL4 PRPF38A PTPN1 RBM39 RNPS1 RSRP1 SDCBP SNIP1 SNRNP70 SRPK2 SRRM1 TRIM27 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF263 ZNF394 ZNF398 ZNF473 ZRSR2
Entrez ID		1889	1196
HPRD ID		02690	04289
Ensembl ID		ENSG00000117298	ENSG00000176444
Uniprot IDs		B4DKB2 P42892	A8K7I0 B1AVT0 B7Z8N6 P49760 Q9BRG8
PDB IDs		3DWB	3NR9
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Renal Sodium Excretion Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Muscle System Process Regulation Of Neurological System Process Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Circulation Artery Smooth Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure Renal System Process Tonic Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Vascular Smooth Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Urine Volume Negative Regulation Of Tissue Remodeling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Homeostasis Muscle Contraction Muscle Hypertrophy Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cell Differentiation Chemical Homeostasis Positive Regulation Of Vasodilation Vasoconstriction Negative Regulation Of Cellular Metabolic Process Cellular Calcium Ion Homeostasis Positive Regulation Of Oxidoreductase Activity Calcium Ion Homeostasis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Secretion Aging Positive Regulation Of Cell Migration Regulation Of Vasodilation Positive Regulation Of Cell Motility	MRNA Processing RNA Processing RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression Termination Of RNA Polymerase II Transcription RNA Metabolic Process DNA-templated Transcription, Termination MRNA 3'-end Processing Cellular Nitrogen Compound Metabolic Process RNA 3'-end Processing Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome MRNA Export From Nucleus RNA Export From Nucleus Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of RNA Metabolic Process Regulation Of MRNA Processing Transcription, DNA-templated RNA Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Cellular Process Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Macromolecule Biosynthetic Process Nuclear Export MRNA Transport Negative Regulation Of Transferase Activity Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Protein Phosphorylation Protein Ubiquitination Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Transport Protein Modification By Small Protein Conjugation RNA Localization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Phosphorylation
Tagcloud ?		5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin genetics hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype	chek2 comprehensively escc esophageal fance fen1 gc genetics genotyped germline gtf2h3 han hel308 linxian mpg mre11a pole polq propensity rad54b rad54l resampling shanxi smug1 snps sum tdg validate warranted
Tagcloud (Difference) ?		5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype	chek2 comprehensively escc esophageal fance fen1 gc genotyped germline gtf2h3 han hel308 linxian mpg mre11a pole polq propensity rad54b rad54l resampling shanxi smug1 snps sum tdg validate warranted
Tagcloud (Intersection) ?		genetics