ECE1 and CALCA

Number of citations of the paper that reports this interaction (PubMedID 18039931)
51

Data Source:
BioGRID (enzymatic study)

		ECE1	CALCA
Description		endothelin converting enzyme 1	calcitonin related polypeptide alpha
Image
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding	Signaling Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding Protein-containing Complex Binding Receptor Ligand Activity
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Signal Transduction G Protein-coupled Receptor Signaling Pathway Axon Guidance Heart Development Anatomical Structure Morphogenesis Gene Expression Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Neuron Projection Development Endothelin Maturation Embryonic Heart Tube Development Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development Axonogenesis Involved In Innervation Sympathetic Neuron Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Response To Yeast Endothelial Cell Proliferation Vasculature Development Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Embryo Implantation Regulation Of Blood Pressure Negative Regulation Of Calcium Ion Transport Into Cytosol Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Vasodilation Endothelial Cell Migration Innate Immune Response Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Contraction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Tumor Necrosis Factor Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors	G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs		5-(2-hydroxyethyl)nonane-1,9-diol	Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Feeling worry ( 29500382) Height ( 25282103) Longevity (age >90th survival percentile) ( 31413261) Morning person ( 30696823) Obesity-related traits ( 23251661) Weight ( 28552196)	Diverticular disease ( 30177863) Hip circumference adjusted for BMI ( 34021172) Vitamin D levels ( 25208829)
Interacting Genes		14 interacting genes: AGT CALCA CLK1 CLK2 CYSRT1 EDN1 KNG1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-8 MTDH MTNR1A MYOC	8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2
Entrez ID		1889	796
HPRD ID		02690	00238
Ensembl ID		ENSG00000117298	ENSG00000110680
Uniprot IDs		P42892	P01258 P06881
PDB IDs		3DWB	2JXZ 6E3Y 7KNU 7TYH 7TYO 9AUC
Enriched GO Terms of Interacting Partners?		Keratin Filament Hormone Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Intermediate Filament Skeletal Muscle Adaptation Regulation Of Renal Sodium Excretion Vascular Process In Circulatory System Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Renal Sodium Ion Transport Receptor Ligand Activity Renal Sodium Ion Absorption Circulatory System Process Positive Regulation Of Extracellular Matrix Organization Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Vasoconstriction Regulation Of Blood Pressure Positive Regulation Of Cardiac Muscle Hypertrophy Response To Testosterone Renal Absorption Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Response To Dexamethasone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endothelin A Receptor Binding Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Rhythmic Excitation Skeletal Muscle Hypertrophy G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of Coagulation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Muscle Cell Apoptotic Process Cellular Response To Glucocorticoid Stimulus Regulation Of Muscle System Process Regulation Of Smooth Muscle Contraction Muscle System Process Regulation Of Extracellular Matrix Organization Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Membrane Hyperpolarization Negative Regulation Of Cation Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Type 2 Angiotensin Receptor Binding Regulation Of Monoatomic Cation Transmembrane Transport	Calcitonin Family Receptor Signaling Pathway Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Amylin Receptor Signaling Pathway BBSome Receptor Internalization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Striatum Development Regulation Of Cilium Beat Frequency Retina Homeostasis Brain Morphogenesis Ventricular System Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Face Development Regulation Of Blood Pressure Receptor-mediated Endocytosis Protein Localization To Plasma Membrane Establishment Of Protein Localization Regulation Of Cilium Movement Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Photoreceptor Cell Maintenance Calcium Ion Transport Dendrite Development Heart Development Non-motile Cilium Assembly Regulation Of Microtubule-based Movement G Protein-coupled Receptor Signaling Pathway Ciliary Membrane Protein Localization To Membrane Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Coreceptor Activity Protein Localization To Cilium Endothelin Maturation Calcitonin Catabolic Process Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Binding Hippocampus Development Intracellular Protein Localization Sensory Perception Of Smell Cerebral Cortex Development Metalloendopeptidase Activity Endocytosis
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