ECE1 and MTDH

Number of citations of the paper that reports this interaction (PubMedID 22199357)
32

Data Source:
BioGRID (unspecified method)

		ECE1	MTDH
Description		endothelin converting enzyme 1	metadherin
Image
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Fibrillar Center Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Signal Transduction G Protein-coupled Receptor Signaling Pathway Axon Guidance Heart Development Anatomical Structure Morphogenesis Gene Expression Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Neuron Projection Development Endothelin Maturation Embryonic Heart Tube Development Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development Axonogenesis Involved In Innervation Sympathetic Neuron Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Peptide ligand-binding receptors
Drugs		5-(2-hydroxyethyl)nonane-1,9-diol
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Feeling worry ( 29500382) Height ( 25282103) Longevity (age >90th survival percentile) ( 31413261) Morning person ( 30696823) Obesity-related traits ( 23251661) Weight ( 28552196)	Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Sweet taste preference ( 32572145)
Interacting Genes		14 interacting genes: AGT CALCA CLK1 CLK2 CYSRT1 EDN1 KNG1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-8 MTDH MTNR1A MYOC	175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPAP CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 FOXM1 GHDC GLG1 GRID1 HACE1 HERC5 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC38A4 SLC67A1-AS SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 UBXN7 VIM WDFY2 WNK2 ZNF559 ZXDC
Entrez ID		1889	92140
HPRD ID		02690	17459
Ensembl ID		ENSG00000117298	ENSG00000147649
Uniprot IDs		P42892	Q86UE4
PDB IDs		3DWB	4QMG
Enriched GO Terms of Interacting Partners?		Keratin Filament Hormone Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Intermediate Filament Skeletal Muscle Adaptation Regulation Of Renal Sodium Excretion Vascular Process In Circulatory System Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Renal Sodium Ion Transport Receptor Ligand Activity Renal Sodium Ion Absorption Circulatory System Process Positive Regulation Of Extracellular Matrix Organization Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Vasoconstriction Regulation Of Blood Pressure Positive Regulation Of Cardiac Muscle Hypertrophy Response To Testosterone Renal Absorption Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Response To Dexamethasone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endothelin A Receptor Binding Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Rhythmic Excitation Skeletal Muscle Hypertrophy G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of Coagulation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Muscle Cell Apoptotic Process Cellular Response To Glucocorticoid Stimulus Regulation Of Muscle System Process Regulation Of Smooth Muscle Contraction Muscle System Process Regulation Of Extracellular Matrix Organization Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Membrane Hyperpolarization Negative Regulation Of Cation Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Type 2 Angiotensin Receptor Binding Regulation Of Monoatomic Cation Transmembrane Transport	Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Developmental Process Cell Adhesion Extracellular Exosome Cell Surface Receptor Signaling Pathway Angiogenesis Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Receptor Complex Myoblast Fusion Regulation Of Cellular Component Organization Cell Migration Actin Cytoskeleton Organization Cytoskeleton Organization Extracellular Matrix Endodermal Cell Differentiation Actin Filament Binding Homotypic Cell-cell Adhesion Cell-cell Adhesion Z Disc Regulation Of Signaling Cell Motility Ameboidal-type Cell Migration Actin Filament-based Process Membrane Protein Maturation Collagen V Binding Organelle Organization Focal Adhesion Signal Transduction Integrin Binding Cell Morphogenesis Regulation Of Cell Communication Hair Cycle Process Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Cytoskeleton Extracellular Matrix Structural Constituent Skin Development Virus Receptor Activity Cell-substrate Adhesion Golgi Organization Symbiont Entry Into Host Cell Tissue Remodeling Sarcomere Proteoglycan Binding Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?