ECE1

Gene Name		endothelin converting enzyme 1
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Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Endosome Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Heart Development Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Endothelin Maturation Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		8 interactors: AGT CALCA CLK2 EDN1 KNG1 KRTAP10-1 KRTAP10-5 MYOC
Entrez ID		1889
HPRD ID		02690
Ensembl ID		ENSG00000117298
Uniprot IDs		B4DKB2 P42892
PDB IDs		3DWB
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Renal Sodium Excretion Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Muscle System Process Regulation Of Neurological System Process Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Circulation Artery Smooth Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure Renal System Process Tonic Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Vascular Smooth Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Urine Volume Negative Regulation Of Tissue Remodeling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Homeostasis Muscle Contraction Muscle Hypertrophy Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cell Differentiation Chemical Homeostasis Positive Regulation Of Vasodilation Vasoconstriction Negative Regulation Of Cellular Metabolic Process Cellular Calcium Ion Homeostasis Positive Regulation Of Oxidoreductase Activity Calcium Ion Homeostasis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Secretion Aging Positive Regulation Of Cell Migration Regulation Of Vasodilation Positive Regulation Of Cell Motility
Tagcloud ?		5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin genetics hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype