ECE1 and EDN1

Number of citations of the paper that reports this interaction (PMID 10438732)
14

Data Source:
HPRD (in vivo, in vitro)

		ECE1	EDN1
Gene Name		endothelin converting enzyme 1	endothelin 1
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Endosome Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Weibel-Palade Body Basal Part Of Cell Rough Endoplasmic Reticulum Lumen
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding	Cytokine Activity Hormone Activity Protein Binding Endothelin A Receptor Binding Endothelin B Receptor Binding
	Biological Process	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Heart Development Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Endothelin Maturation Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Prostaglandin Biosynthetic Process Patterning Of Blood Vessels In Utero Embryonic Development Histamine Secretion Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of PH Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Heart Development Respiratory Gaseous Exchange Body Fluid Secretion Positive Regulation Of Cell Proliferation Dorsal/ventral Pattern Formation Response To Ozone Multicellular Organismal Aging Positive Regulation Of Heart Rate Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Receptor Biosynthetic Process Neural Crest Cell Development Phosphatidylinositol 3-kinase Signaling Response To Activity Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Glucose Transport Cell Growth Regulation Of Vasoconstriction Sensory Perception Of Pain Calcium-mediated Signaling Peptide Hormone Secretion Nitric Oxide Transport Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Negative Regulation Of CAMP Biosynthetic Process Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Testosterone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Prostaglandin F Response To Nicotine Cellular Response To Drug Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Muscle Stretch Epithelial Fluid Transport Vasoconstriction Protein Kinase C Deactivation Middle Ear Morphogenesis Positive Regulation Of Odontogenesis Superoxide Anion Generation Rhythmic Excitation Response To Amino Acid Positive Regulation Of MAP Kinase Activity Positive Regulation Of JUN Kinase Activity Response To Leptin Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Cartilage Development Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Membrane Depolarization Regulation Of Sensory Perception Of Pain Maternal Process Involved In Parturition Positive Regulation Of Sarcomere Organization Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Calcium Ion Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Neutrophil Chemotaxis Response To Salt
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Circulating vasoactive peptide levels ( 23381795)
Protein-Protein Interactions		8 interactors: AGT CALCA CLK2 EDN1 KNG1 KRTAP10-1 KRTAP10-5 MYOC	10 interactors: ADM BAG6 CMA1 COPS6 ECE1 EDNRA EDNRB KEL MME UBQLN4
Entrez ID		1889	1906
HPRD ID		02690	07030
Ensembl ID		ENSG00000117298	ENSG00000078401
Uniprot IDs		B4DKB2 P42892	P05305 Q6FH53
PDB IDs		3DWB	1EDN 1EDP 1T7H 1V6R
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Renal Sodium Excretion Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Muscle System Process Regulation Of Neurological System Process Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Circulation Artery Smooth Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure Renal System Process Tonic Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Vascular Smooth Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Urine Volume Negative Regulation Of Tissue Remodeling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Homeostasis Muscle Contraction Muscle Hypertrophy Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cell Differentiation Chemical Homeostasis Positive Regulation Of Vasodilation Vasoconstriction Negative Regulation Of Cellular Metabolic Process Cellular Calcium Ion Homeostasis Positive Regulation Of Oxidoreductase Activity Calcium Ion Homeostasis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Secretion Aging Positive Regulation Of Cell Migration Regulation Of Vasodilation Positive Regulation Of Cell Motility	Blood Circulation Regulation Of Blood Pressure Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Endothelin Receptor Signaling Pathway Vasoconstriction Peptide Hormone Processing Hormone Metabolic Process Cellular Chemical Homeostasis Organ Development Regulation Of Hormone Levels Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Calcium Ion Homeostasis Cellular Homeostasis Calcium Ion Homeostasis Regulation Of Protein Metabolic Process Sensory Perception Of Pain Regulation Of CAMP Biosynthetic Process Aging Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of CAMP Metabolic Process Enteric Nervous System Development Chemical Homeostasis Vascular Smooth Muscle Contraction Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Peptide Metabolic Process Metal Ion Homeostasis System Development Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Ion Homeostasis Negative Regulation Of CAMP Biosynthetic Process Cyclic-nucleotide-mediated Signaling Negative Regulation Of CAMP Metabolic Process Multicellular Organismal Development Anatomical Structure Development Protein Processing Nervous System Development Negative Regulation Of Nucleotide Metabolic Process Homeostatic Process Cellular Amide Metabolic Process Tube Development Autonomic Nervous System Development Regulation Of Inflammatory Response Proteolysis
Tagcloud ?		5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin genetics hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype	19q13 6p23 ankyloglossia bcl3 causation cleft disequilibrium exemplify indictment inheritance lip malformation mendelian merely monogenic multigenic nurture orofacial palatal palate parametric pedigrees penetrance recognised rests syndromic tentative teratogenic teratogens
Tagcloud (Difference) ?		5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin genetics hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype	19q13 6p23 ankyloglossia bcl3 causation cleft disequilibrium exemplify indictment inheritance lip malformation mendelian merely monogenic multigenic nurture orofacial palatal palate parametric pedigrees penetrance recognised rests syndromic tentative teratogenic teratogens
Tagcloud (Intersection) ?