UNC119 and LIG4

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		UNC119	LIG4
Description		unc-119 lipid binding chaperone	DNA ligase 4
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Intercellular Bridge Synapse Spindle Midzone	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	Protein Binding Lipid Binding	Nucleotide Binding Magnesium Ion Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding AMP Binding Ligase Activity Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Protein Transport Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Ionizing Radiation Response To Gamma Radiation Neurogenesis T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Stem Cell Proliferation Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining DN2 Thymocyte Differentiation Positive Regulation Of Chromosome Organization
Pathways			2-LTR circle formation Nonhomologous End-Joining (NHEJ)
Drugs
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)
Interacting Genes		104 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CFTR CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24	103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATOSA ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT
Entrez ID		9094	3981
HPRD ID		04927	03500
Ensembl ID		ENSG00000109103	ENSG00000174405
Uniprot IDs		K7EN86 Q13432	A0A0C4DGV9 A8K8Q4 P49917
PDB IDs		3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A 7UMO 9GKG	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG 7D9K 7D9Y 7LSY 7LT3 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Glutamatergic Synapse Leukocyte Migration Positive Regulation Of Cell Activation Cytosol Enzyme Binding Positive Regulation Of Cell-cell Adhesion Protein Binding T Cell Receptor Binding RAGE Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Cell Development Regulation Of Calcium Ion Import Across Plasma Membrane Cytoplasm Nucleus T Cell Activation Positive Regulation Of Monoatomic Ion Transmembrane Transport Gamma-delta T Cell Receptor Complex Lymphocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Calcium-dependent Protein Binding Regulation Of T Cell Activation Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Developmental Process T Cell Costimulation Positive Regulation Of Leukocyte Differentiation T Cell Receptor Complex Intracellular Signaling Cassette CD8 Receptor Binding Nucleotide Binding Gamma-delta T Cell Activation Negative Regulation Of Cell Development Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phagocytosis Regulation Of Leukocyte Proliferation Response To Gamma Radiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Schaffer Collateral - CA1 Synapse	Histone H2AXS139 Kinase Activity Respiratory Electron Transport Chain Electron Transport Chain Aerobic Respiration Aerobic Electron Transport Chain Cellular Respiration Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining ATP Synthesis Coupled Electron Transport Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Repair Generation Of Precursor Metabolites And Energy Macromolecule Metabolic Process V(D)J Recombination Proton Transmembrane Transport Respiratory Chain Complex I DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Protein Localization To Site Of Double-strand Break Energy Derivation By Oxidation Of Organic Compounds Extracellular Exosome Response To Ionizing Radiation DNA Metabolic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Telomere Maintenance Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cytochrome-c Oxidase Activity Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Chromosome Organization Chromosome Organization Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Proton Motive Force-driven ATP Synthesis ATP Metabolic Process NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Response To Radiation DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Positive Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process RNA Binding NADH Dehydrogenase (ubiquinone) Activity Regulation Of Cellular Response To Heat DNA Recombination
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