UNC119 and CD3E

Number of citations of the paper that reports this interaction (PMID 14757743)
21

Data Source:
HPRD (in vitro)

		UNC119	CD3E
Gene Name		unc-119 homolog (C. elegans)	CD3e molecule, epsilon (CD3-TCR complex)
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Binding Lipid Binding	Transmembrane Signaling Receptor Activity Receptor Signaling Protein Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Protein Heterodimerization Activity
	Biological Process	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis	Positive Regulation Of T Cell Anergy Protein Complex Assembly Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G-protein Coupled Receptor Signaling Pathway Response To Nutrient T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Negative Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways			TCR signaling Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family PD-1 signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs			Muromonab
Diseases
GWAS
Protein-Protein Interactions		92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24	19 interactors: CD3D CD3EAP CD3G CD79B CSK LCK NCK1 NCK2 NCL PIK3R1 PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UNC119 ZAP70
Entrez ID		9094	916
HPRD ID		04927	08923
Ensembl ID		ENSG00000109103	ENSG00000198851
Uniprot IDs		Q13432	P07766
PDB IDs		3GQQ 3RBQ 4GOJ 4GOK	1A81 1SY6 1XIW 2ROL
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation	Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Innate Immune Response T Cell Costimulation Cell Migration Cell Motility Immune Response Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Ketone Metabolic Process Signal Transduction Cell Adhesion T Cell Differentiation Locomotion Positive Regulation Of Signal Transduction
Tagcloud ?			acp5 b220 calcitonin calcr cd11b cd2 cd31 cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11
Tagcloud (Difference) ?			acp5 b220 calcitonin calcr cd11b cd2 cd31 cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11
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