UNC119 and IL5RA

Number of citations of the paper that reports this interaction (PubMedID 12496276)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		UNC119	IL5RA
Description		unc-119 lipid binding chaperone	interleukin 5 receptor subunit alpha
Image
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Intercellular Bridge Synapse Spindle Midzone	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding Lipid Binding	Cytokine Receptor Activity Interleukin-5 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Protein Transport Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis	Inflammatory Response To Antigenic Stimulus Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Eosinophil Differentiation Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways			Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs			Dimethyl sulfoxide Benralizumab
Diseases
GWAS			Asthma (childhood onset) ( 22560479) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Oleic acid (18:1n-9) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		104 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CFTR CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24	7 interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119
Entrez ID		9094	3568
HPRD ID		04927	00998
Ensembl ID		ENSG00000109103	ENSG00000091181
Uniprot IDs		K7EN86 Q13432	Q01344 Q8NHV7
PDB IDs		3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A 7UMO 9GKG	1OBX 1OBZ 3QT2 3VA2 6H41 8TLD
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Glutamatergic Synapse Leukocyte Migration Positive Regulation Of Cell Activation Cytosol Enzyme Binding Positive Regulation Of Cell-cell Adhesion Protein Binding T Cell Receptor Binding RAGE Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Cell Development Regulation Of Calcium Ion Import Across Plasma Membrane Cytoplasm Nucleus T Cell Activation Positive Regulation Of Monoatomic Ion Transmembrane Transport Gamma-delta T Cell Receptor Complex Lymphocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Calcium-dependent Protein Binding Regulation Of T Cell Activation Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Developmental Process T Cell Costimulation Positive Regulation Of Leukocyte Differentiation T Cell Receptor Complex Intracellular Signaling Cassette CD8 Receptor Binding Nucleotide Binding Gamma-delta T Cell Activation Negative Regulation Of Cell Development Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phagocytosis Regulation Of Leukocyte Proliferation Response To Gamma Radiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Schaffer Collateral - CA1 Synapse	Interleukin-5-mediated Signaling Pathway Interleukin-5 Receptor Binding Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Interleukin-3 Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Binding Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Focal Adhesion Regulation Of Phosphorylation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein Tyrosine Kinase Activity Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Leukocyte Proliferation Regulation Of Phosphorus Metabolic Process Growth Hormone Receptor Signaling Pathway Signal Transduction Membrane Raft Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Phosphorylation Response To Antibiotic Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Leukocyte Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Multivesicular Body, Internal Vesicle Lumen Regulation Of Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Cellular Response To Virus Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Interleukin-35-mediated Signaling Pathway Negative Regulation Of Endocytosis Interleukin-5 Receptor Complex Cellular Response To Cytokine Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?