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LIG4 and ATR
Number of citations of the paper that reports this interaction (PubMedID
10608806
)
0
Data Source:
BioGRID
(unspecified method)
LIG4
ATR
Description
DNA ligase 4
ATR checkpoint kinase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Nonhomologous End Joining Complex
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Chromosome
Golgi Apparatus
PML Body
ATR-ATRIP Complex
Site Of DNA Damage
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
AMP Binding
Ligase Activity
Metal Ion Binding
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Histone H2AXS139 Kinase Activity
Protein Serine Kinase Activity
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Repair
Base-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Ionizing Radiation
Response To Gamma Radiation
Neurogenesis
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Stem Cell Proliferation
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
DN2 Thymocyte Differentiation
Positive Regulation Of Chromosome Organization
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Telomere Maintenance
Nucleobase-containing Compound Metabolic Process
DNA Replication
DNA Repair
Double-strand Break Repair
Chromatin Remodeling
DNA Damage Response
Nuclear Envelope Organization
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Replication Fork Processing
Positive Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To UV
Interstrand Cross-link Repair
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitotic G2/M Transition Checkpoint
Response To Arsenic-containing Substance
Nuclear Membrane Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Gamma Radiation
Regulation Of Cellular Response To Stress
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Protein Localization To Site Of Double-strand Break
Regulation Of Double-strand Break Repair
Pathways
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
Meiotic synapsis
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Ceralasertib
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Alveolar rhabdomyosarcoma
Seckel syndrome
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Eosinophil count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
29403010
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
27863252
29403010
32888494
)
Red cell distribution width (
28957414
32888494
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATOSA
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
58 interacting genes:
AATF
ABL1
AP1B1
AP3B1
APBB1
ARHGEF1
ATM
BLM
BRCA1
BRCA2
CDKN2C
CEP164
CHD4
CHEK1
CHEK2
CHUK
CLSPN
CREB1
DCAF1
DCLRE1C
DTL
E2F1
E4F1
EEF1E1
EP300
ETAA1
ETV1
FANCA
FANCD2
FANCI
FLT1
H2AX
KDR
LIG4
MCM2
MCPH1
MRE11
MSH2
NBN
NFE2L2
PA2G4
PARP1
PIK3CA
POLD1
POLN
PPP2R3A
RAD17
RASSF1
RHEB
RPA1
TP53
TREX1
UHRF1
UHRF2
UPF1
USP2-AS1
XPA
XRCC5
Entrez ID
3981
545
HPRD ID
03500
08369
Ensembl ID
ENSG00000174405
ENSG00000175054
Uniprot IDs
A0A0C4DGV9
A8K8Q4
P49917
Q13535
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
7D9K
7D9Y
7LSY
7LT3
7NFC
7NFE
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
5YZ0
Enriched GO Terms of Interacting Partners
?
Histone H2AXS139 Kinase Activity
Respiratory Electron Transport Chain
Electron Transport Chain
Aerobic Respiration
Aerobic Electron Transport Chain
Cellular Respiration
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
ATP Synthesis Coupled Electron Transport
Positive Regulation Of Signal Transduction By P53 Class Mediator
DNA Repair
Generation Of Precursor Metabolites And Energy
Macromolecule Metabolic Process
V(D)J Recombination
Proton Transmembrane Transport
Respiratory Chain Complex I
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair
Immunoglobulin V(D)J Recombination
Nonhomologous End Joining Complex
Protein Localization To Site Of Double-strand Break
Energy Derivation By Oxidation Of Organic Compounds
Extracellular Exosome
Response To Ionizing Radiation
DNA Metabolic Process
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Double-strand Break Repair
Telomere Maintenance
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Cytochrome-c Oxidase Activity
Proton Motive Force-driven Mitochondrial ATP Synthesis
Positive Regulation Of Chromosome Organization
Chromosome Organization
Protein Localization To Chromosome
Positive Regulation Of DNA Metabolic Process
Proton Motive Force-driven ATP Synthesis
ATP Metabolic Process
NADH Dehydrogenase Complex Assembly
Mitochondrial Respiratory Chain Complex I Assembly
Response To Radiation
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Repair
Positive Regulation Of Telomere Maintenance
Regulation Of Protein Metabolic Process
RNA Binding
NADH Dehydrogenase (ubiquinone) Activity
Regulation Of Cellular Response To Heat
DNA Recombination
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleic Acid Metabolic Process
Double-strand Break Repair
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
Chromosome, Telomeric Region
Mitotic DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
DNA Recombination
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Macromolecule Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Nucleoplasm
Recombinational Repair
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Response To Radiation
Damaged DNA Binding
Double-strand Break Repair Via Homologous Recombination
Mitotic G2/M Transition Checkpoint
Cellular Response To Radiation
Chromosome Organization
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Primary Metabolic Process
Response To Gamma Radiation
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
Mitotic G2 DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
DNA Binding
Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Telomere Maintenance
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
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