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UNC119 and HLA-DQA1
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
HPRD
(two hybrid)
UNC119
HLA-DQA1
Gene Name
unc-119 homolog (C. elegans)
major histocompatibility complex, class II, DQ alpha 1
Image
Gene Ontology Annotations
Cellular Component
Spindle Pole
Centrosome
Cytosol
Intercellular Bridge
Spindle Midzone
Golgi Membrane
Lysosomal Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Endosome Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Protein Binding
Lipid Binding
MHC Class II Receptor Activity
Peptide Antigen Binding
Biological Process
Endocytosis
Cytokinesis, Completion Of Separation
Synaptic Transmission
Visual Perception
Phototransduction
Lipoprotein Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Clathrin-mediated Endocytosis
Negative Regulation Of Caveolin-mediated Endocytosis
Immune Response
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
Positive Regulation Of T Cell Differentiation
T Cell Receptor Signaling Pathway
Interferon-gamma-mediated Signaling Pathway
Pathways
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Drugs
Diseases
GWAS
Asthma (
23181788
)
Celiac disease (
20190752
17558408
)
Cervical cancer (
23482656
)
Chronic lymphocytic leukemia (
21131588
)
Crohn's disease (
23266558
)
Hepatocellular carcinoma (
22807686
)
Hypothyroidism (
22493691
)
Immune response to anthrax vaccine (
22658931
)
Inflammatory bowel disease (
18758464
)
Leishmaniasis (visceral) (
23291585
)
Lymphoma (
23349640
)
Multiple sclerosis (OCB status) (
23472185
)
Nephropathy (
21399633
)
Nephropathy (idiopathic membranous) (
21323541
)
Prostate cancer (
23535732
)
Response to interferon beta therapy (
21502966
)
Rheumatoid arthritis (
18668548
21653640
)
Schizophrenia (
23212062
19571809
)
Systemic lupus erythematosus (
18204098
21408207
)
Systemic sclerosis (
21779181
)
Ulcerative colitis (
23128233
21297633
19122664
23511034
)
Vitiligo (
20410501
)
Protein-Protein Interactions
92 interactors:
AAGAB
ALDH2
AMOT
ANKRD24
ANXA1
ANXA3
ANXA7
ARL15
ARL2
ARL3
ARL4D
ASH2L
BCR
BRIX1
BTBD2
C16orf74
CBX8
CCL18
CD247
CD3E
CD4
CDC42
CDKN1A
CDKN2C
CETN3
CKMT2
CKS2
COX17
CYB561D2
EIF2S2
ERH
FKBPL
FXYD6
FYN
GIPC2
GSTM4
HCK
HLA-DQA1
HMGB1
HSPB3
HSPE1
ID2
IL5RA
ITSN1
KDM1A
LAMA4
LCK
LIG4
LUC7L2
LYN
MAPK10
MAPK8IP2
MPHOSPH6
MRPS12
ORAI2
PAFAH1B3
PAPSS1
PCDHA4
PFN1
PHF10
PIN1
PPA1
PPAP2C
PSMD11
PSMD2
PTPRS
QTRT1
RAP1B
RCC1
RFC5
RGL2
RPA2
RPS6KA5
RUFY3
S100A4
S100A8
SAT1
SEPHS1
SERPINB9
SMN1
SULT1E1
TK1
TP53BP2
TP53I3
TRDMT1
TSC22D1
UBE2B
UBE2I
UBQLN4
ZAK
ZFP64
ZNF24
8 interactors:
APLP1
CD74
CDK7
IKBKG
LRIF1
SH3GL2
TLE1
UNC119
Entrez ID
9094
3117
HPRD ID
04927
06765
Ensembl ID
ENSG00000109103
ENSG00000196735
Uniprot IDs
Q13432
B7ZW51
L8E864
P01909
Q08AS3
Q30063
Q5Y7H0
Q8MH44
PDB IDs
3GQQ
3RBQ
4GOJ
4GOK
1JK8
1NBN
1S9V
1UVQ
2NNA
4GG6
Enriched GO Terms of Interacting Partners
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T Cell Costimulation
Regulation Of Catalytic Activity
Response To Stress
Developmental Process
Immune System Process
Regulation Of Defense Response To Virus By Virus
System Development
Anatomical Structure Development
Positive Regulation Of Catalytic Activity
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Response To Stimulus
Immune Response
Regulation Of Apoptotic Process
Defense Response
Cell Cycle
Nervous System Development
Regulation Of Cellular Protein Metabolic Process
Multicellular Organismal Development
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Death
Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Positive Regulation Of Transferase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Regulation Of Cell Activation
Regulation Of Cell Cycle
Innate Immune Response
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell-cell Adhesion
Leukocyte Differentiation
T Cell Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Protein Modification Process
Viral Process
Positive Regulation Of Intracellular Signal Transduction
Cell Differentiation
Positive Regulation Of Metabolic Process
Cell Activation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Signal Transduction
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Phosphorylation
Negative Regulation Of Signal Transduction
Negative Regulation Of Intracellular Signal Transduction
Signaling
Regulation Of Protein Metabolic Process
Cell Communication
Negative Regulation Of Clathrin-mediated Endocytosis
Macrophage Migration Inhibitory Factor Signaling Pathway
Negative Regulation Of Signaling
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of Protein Kinase Activity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Positive Regulation Of Kinase Activity
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Phosphorylation
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Positive Regulation Of Transferase Activity
Negative Regulation Of Caveolin-mediated Endocytosis
Cellular Response To Stimulus
Activation Of MAPK Activity
Cytokinesis, Completion Of Separation
Cellular Response To Norepinephrine Stimulus
Endocytosis
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Mature B Cell Apoptotic Process
Positive Regulation Of Protein Phosphorylation
Cell Surface Receptor Signaling Pathway
Regulation Of Endocytosis
RNA Metabolic Process
Response To Norepinephrine
Intracellular Receptor Signaling Pathway
Establishment Of Vesicle Localization
Regulation Of Peptidyl-tyrosine Phosphorylation
Vesicle Localization
Positive Regulation Of MAP Kinase Activity
Regulation Of Caveolin-mediated Endocytosis
Positive Regulation Of Phosphorylation
Positive Regulation Of Metabolic Process
Gene Expression
Mitotic Cytokinetic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
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Tagcloud (Intersection)
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