UNC119 and PAPSS1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		UNC119	PAPSS1
Gene Name		unc-119 homolog (C. elegans)	3-phosphoadenosine 5-phosphosulfate synthase 1
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Gene Ontology Annotations	Cellular Component	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone	Cytosol
	Molecular Function	Protein Binding Lipid Binding	Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity ATP Binding Nucleotidyltransferase Activity
	Biological Process	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis	Sulfate Assimilation Skeletal System Development Carbohydrate Metabolic Process Xenobiotic Metabolic Process Pathogenesis Phosphorylation Glycosaminoglycan Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways			MPS IIIB - Sanfilippo syndrome B Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective UGT1A1 causes hyperbilirubinemia Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) MPS IIIC - Sanfilippo syndrome C Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Phase II conjugation Transport and synthesis of PAPS Cytosolic sulfonation of small molecules Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B Transport and synthesis of PAPS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24	3 interactors: EEF1A1 PPP1R16A UNC119
Entrez ID		9094	9061
HPRD ID		04927	09132
Ensembl ID		ENSG00000109103	ENSG00000138801
Uniprot IDs		Q13432	O43252 Q6IAX6
PDB IDs		3GQQ 3RBQ 4GOJ 4GOK	1X6V 1XJQ 1XNJ 2OFW 2OFX 2PEY 2PEZ 2QJF
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation	Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Regulation Of Clathrin-mediated Endocytosis Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Protein Tyrosine Kinase Activity Mitotic Cytokinesis Negative Regulation Of Endocytosis Regulation Of Protein Tyrosine Kinase Activity
Tagcloud ?			adenovirus adjacent arresting believed catalyzing cck comparatively cycles discrepancies downregulating endometrial estrogen estrogens expressions mcf meanwhile proliferating prominent retarded subcutaneous sulfate sulfation sult1e1 tumorous universal upregulating xenograft
Tagcloud (Difference) ?			adenovirus adjacent arresting believed catalyzing cck comparatively cycles discrepancies downregulating endometrial estrogen estrogens expressions mcf meanwhile proliferating prominent retarded subcutaneous sulfate sulfation sult1e1 tumorous universal upregulating xenograft
Tagcloud (Intersection) ?