LIG4 and CTSK

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		LIG4	CTSK
Gene Name		ligase IV, DNA, ATP-dependent	cathepsin K
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Extracellular Region Extracellular Space Endolysosome Lumen
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Ligation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion DNA Biosynthetic Process Establishment Of Integrated Proviral Latency	Intramembranous Ossification Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Bone Resorption Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle	Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen degradation Activation of Matrix Metalloproteinases MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)	Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		103 interactors: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 CAP1 CCDC176 CLU COL1A2 COMMD1 COX1 COX2 COX3 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C ND1 ND4 ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	6 interactors: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC
Entrez ID		3981	1513
HPRD ID		03500	03064
Ensembl ID		ENSG00000174405	ENSG00000143387
Uniprot IDs		P49917	P43235
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP	1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 7PCK
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization DNA Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress Metabolic Process Cell Cycle Process Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Response To Stress Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Mitochondrial Electron Transport, NADH To Ubiquinone Mitotic Cell Cycle Checkpoint Positive Regulation Of Signal Transduction By P53 Class Mediator Viral Process Response To Radiation Mitotic Cell Cycle Process Protein Metabolic Process Negative Regulation Of Cell Cycle Response To Gamma Radiation Posttranscriptional Regulation Of Gene Expression Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Translation Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Electron Transport Chain Regulation Of Protein Ubiquitination Regulation Of Response To DNA Damage Stimulus Cell Cycle V(D)J Recombination Pro-B Cell Differentiation Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Ubiquitin-protein Transferase Activity	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Somatic Stem Cell Maintenance Platelet Degranulation Regulation Of Endothelial Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway DNA Ligation Involved In DNA Recombination Regulation Of Proteolysis Negative Regulation Of Epithelial Cell Proliferation Cell Activation Response To Wounding Stem Cell Maintenance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Inner Ear Development Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Catalytic Activity Bone Development Ear Development Lagging Strand Elongation Pro-B Cell Differentiation Alveolar Secondary Septum Development Regulation Of Neuron Apoptotic Process Lung Development Axonogenesis Involved In Innervation Stem Cell Development Respiratory Tube Development Response To Abiotic Stimulus Response To Stimulus Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Integrated Proviral Latency Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Respiratory System Development Regulation Of Epithelial Cell Proliferation Regulation Of Neuron Death Immunoglobulin V(D)J Recombination Chondrocyte Proliferation Response To L-ascorbic Acid Establishment Of Viral Latency
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Difference) ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Intersection) ?