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LIG4 and SNX3
Number of citations of the paper that reports this interaction (PubMedID
22990118
)
93
Data Source:
BioGRID
(two hybrid)
LIG4
SNX3
Description
DNA ligase 4
sorting nexin 3
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Nonhomologous End Joining Complex
Cytoplasm
Endosome
Early Endosome
Cytosol
Endosome Membrane
Clathrin-coated Vesicle
Retromer Complex
Cytoplasmic Vesicle
Early Endosome Membrane
Early Phagosome
Phagocytic Vesicle
Extracellular Exosome
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
AMP Binding
Ligase Activity
Metal Ion Binding
Protein Binding
Lipid Binding
Phosphatidylinositol-5-phosphate Binding
Protein Phosphatase Binding
Phosphatidylinositol-3-phosphate Binding
Phosphatidylinositol Binding
Phosphatidylinositol-4-phosphate Binding
Phosphatidylinositol-3,5-bisphosphate Binding
Phosphatidylinositol Phosphate Binding
Retromer Complex Binding
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Repair
Base-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Ionizing Radiation
Response To Gamma Radiation
Neurogenesis
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Stem Cell Proliferation
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
DN2 Thymocyte Differentiation
Positive Regulation Of Chromosome Organization
Response To Bacterium
Membrane Invagination
Positive Regulation Of Neuron Projection Development
Protein Transport
Protein To Membrane Docking
Regulation Of Wnt Signaling Pathway
Endocytic Recycling
Late Endosome To Golgi Transport
Negative Regulation Of Protein Catabolic Process
Host-mediated Suppression Of Symbiont Invasion
Negative Regulation Of Phagocytosis
Negative Regulation Of Protein Transport
Intralumenal Vesicle Formation
Negative Regulation Of Early Endosome To Late Endosome Transport
Pathways
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
WNT ligand biogenesis and trafficking
Ub-specific processing proteases
Drugs
S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Interacting Genes
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATOSA
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
10 interacting genes:
ARL6IP1
BARD1
BRCA1
LIG4
PAXIP1
RPRM
SCNN1A
STX11
TSC22D2
USP10
Entrez ID
3981
8724
HPRD ID
03500
09333
Ensembl ID
ENSG00000174405
ENSG00000112335
Uniprot IDs
A0A0C4DGV9
A8K8Q4
P49917
O60493
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
7D9K
7D9Y
7LSY
7LT3
7NFC
7NFE
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
2MXC
2YPS
5F0J
5F0L
5F0M
5F0P
7BLO
Enriched GO Terms of Interacting Partners
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Histone H2AXS139 Kinase Activity
Respiratory Electron Transport Chain
Electron Transport Chain
Aerobic Respiration
Aerobic Electron Transport Chain
Cellular Respiration
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
ATP Synthesis Coupled Electron Transport
Positive Regulation Of Signal Transduction By P53 Class Mediator
DNA Repair
Generation Of Precursor Metabolites And Energy
Macromolecule Metabolic Process
V(D)J Recombination
Proton Transmembrane Transport
Respiratory Chain Complex I
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair
Immunoglobulin V(D)J Recombination
Nonhomologous End Joining Complex
Protein Localization To Site Of Double-strand Break
Energy Derivation By Oxidation Of Organic Compounds
Extracellular Exosome
Response To Ionizing Radiation
DNA Metabolic Process
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Double-strand Break Repair
Telomere Maintenance
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Cytochrome-c Oxidase Activity
Proton Motive Force-driven Mitochondrial ATP Synthesis
Positive Regulation Of Chromosome Organization
Chromosome Organization
Protein Localization To Chromosome
Positive Regulation Of DNA Metabolic Process
Proton Motive Force-driven ATP Synthesis
ATP Metabolic Process
NADH Dehydrogenase Complex Assembly
Mitochondrial Respiratory Chain Complex I Assembly
Response To Radiation
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Repair
Positive Regulation Of Telomere Maintenance
Regulation Of Protein Metabolic Process
RNA Binding
NADH Dehydrogenase (ubiquinone) Activity
Regulation Of Cellular Response To Heat
DNA Recombination
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
BRCA1-BARD1 Complex
Response To Ionizing Radiation
BRCA1-B Complex
Nuclear Ubiquitin Ligase Complex
BRCA1-C Complex
DNA Repair
BRCA1-A Complex
Ubiquitin-modified Histone Reader Activity
Cellular Response To Ionizing Radiation
DNA Recombination
DNA Strand Resection Involved In Replication Fork Processing
DNA Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
DNA Damage Response
Regulation Of DNA Damage Checkpoint
Response To Radiation
Signal Transduction In Response To DNA Damage
Protein K6-linked Ubiquitination
Cellular Response To Radiation
Regulation Of Cell Cycle
Condensed Chromosome
Postreplication Repair
Homologous Recombination
DNA Damage Response, Signal Transduction By P53 Class Mediator
Chromatin Remodeling
Mitotic G2/M Transition Checkpoint
Negative Regulation Of MRNA 3'-end Processing
Establishment Of Integrated Proviral Latency
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
P53 Binding
Negative Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle
Chromatin Organization
Negative Regulation Of Apoptotic Process
Cellular Response To Stress
Establishment Of Viral Latency
Negative Regulation Of Stress Granule Assembly
DNA Biosynthetic Process
Negative Regulation Of Programmed Cell Death
Signal Transduction By P53 Class Mediator
Ubiquitin Ligase Complex
Regulation Of Cell Cycle Phase Transition
Regulation Of G2/M Transition Of Mitotic Cell Cycle
DNA Ligase (ATP) Activity
DNA Ligase IV Complex
DNA Ligase Activity
Chorion Development
Pro-B Cell Differentiation
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Tagcloud (Intersection)
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