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LIG4 and PEX10
Number of citations of the paper that reports this interaction (PubMedID
22990118
)
93
Data Source:
BioGRID
(two hybrid)
LIG4
PEX10
Description
DNA ligase 4
peroxisomal biogenesis factor 10
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Nonhomologous End Joining Complex
Peroxisome
Peroxisomal Membrane
Membrane
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
AMP Binding
Ligase Activity
Metal Ion Binding
Protein Binding
Zinc Ion Binding
Protein Transmembrane Transporter Activity
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Repair
Base-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Ionizing Radiation
Response To Gamma Radiation
Neurogenesis
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Stem Cell Proliferation
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
DN2 Thymocyte Differentiation
Positive Regulation Of Chromosome Organization
Protein Polyubiquitination
Pexophagy
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Peroxisome Organization
Protein Transport
Protein Import Into Peroxisome Matrix
Protein Import Into Peroxisome Matrix, Receptor Recycling
Protein Ubiquitination
Cellular Response To Reactive Oxygen Species
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Unfolding
Protein Import Into Peroxisome Matrix, Substrate Release
Pathways
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
Peroxisomal protein import
Peroxisomal protein import
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Body mass index (
26426971
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Non-obstructive azoospermia (
22197933
)
Interacting Genes
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATOSA
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
10 interacting genes:
CGRRF1
HNRNPD
LIG4
MKRN3
PCGF6
PEX12
PEX19
PEX2
PEX5
UBE2I
Entrez ID
3981
5192
HPRD ID
03500
04175
Ensembl ID
ENSG00000174405
ENSG00000157911
Uniprot IDs
A0A0C4DGV9
A8K8Q4
P49917
D6RA89
O60683
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
7D9K
7D9Y
7LSY
7LT3
7NFC
7NFE
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
Enriched GO Terms of Interacting Partners
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Histone H2AXS139 Kinase Activity
Respiratory Electron Transport Chain
Electron Transport Chain
Aerobic Respiration
Aerobic Electron Transport Chain
Cellular Respiration
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
ATP Synthesis Coupled Electron Transport
Positive Regulation Of Signal Transduction By P53 Class Mediator
DNA Repair
Generation Of Precursor Metabolites And Energy
Macromolecule Metabolic Process
V(D)J Recombination
Proton Transmembrane Transport
Respiratory Chain Complex I
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair
Immunoglobulin V(D)J Recombination
Nonhomologous End Joining Complex
Protein Localization To Site Of Double-strand Break
Energy Derivation By Oxidation Of Organic Compounds
Extracellular Exosome
Response To Ionizing Radiation
DNA Metabolic Process
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Double-strand Break Repair
Telomere Maintenance
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Cytochrome-c Oxidase Activity
Proton Motive Force-driven Mitochondrial ATP Synthesis
Positive Regulation Of Chromosome Organization
Chromosome Organization
Protein Localization To Chromosome
Positive Regulation Of DNA Metabolic Process
Proton Motive Force-driven ATP Synthesis
ATP Metabolic Process
NADH Dehydrogenase Complex Assembly
Mitochondrial Respiratory Chain Complex I Assembly
Response To Radiation
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Repair
Positive Regulation Of Telomere Maintenance
Regulation Of Protein Metabolic Process
RNA Binding
NADH Dehydrogenase (ubiquinone) Activity
Regulation Of Cellular Response To Heat
DNA Recombination
Peroxisomal Membrane Transport
Establishment Of Protein Localization To Peroxisome
Peroxisome Organization
Protein Import Into Peroxisome Matrix, Substrate Release
Protein Targeting To Peroxisome
Protein Import Into Peroxisome Matrix, Receptor Recycling
Protein Unfolding
Protein Import Into Peroxisome Matrix
Peroxisomal Membrane
Pexophagy
Peroxisome Membrane Targeting Sequence Binding
Receptor Recycling
Intracellular Protein Transmembrane Transport
Peroxisome
Receptor Metabolic Process
Protein Monoubiquitination
Protein Import Into Peroxisome Membrane
Protein Transmembrane Transport
Intracellular Protein Transport
Protein Carrier Chaperone
Lipid Catabolic Process
Cellular Response To Reactive Oxygen Species
Establishment Of Protein Localization To Organelle
Protein Modification By Small Protein Conjugation
Intracellular Transport
Catabolic Process
Protein-containing Complex Disassembly
Post-translational Protein Modification
Protein Transmembrane Transporter Activity
Macroautophagy
Response To Reactive Oxygen Species
Very Long-chain Fatty Acid Metabolic Process
Cellular Localization
Establishment Of Localization In Cell
Protein Targeting
Cellular Response To Oxidative Stress
Protein Transport
Hepatocyte Dedifferentiation
Cellular Response To Putrescine
Establishment Of Integrated Proviral Latency
Protein Ubiquitination
Negative Regulation Of Lipid Binding
Peroxisome Membrane Class-1 Targeting Sequence Binding
Fatty Acid Beta-oxidation
SUMO Conjugating Enzyme Activity
Protein Localization To Organelle
Cellular Response To Chemical Stress
Autophagy
Establishment Of Protein Localization
Circadian Regulation Of Translation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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