LIG4 and AFTPH

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LIG4	AFTPH
Description		DNA ligase 4	aftiphilin
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding AMP Binding Ligase Activity Metal Ion Binding	Protein Binding Clathrin Binding
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Ionizing Radiation Response To Gamma Radiation Neurogenesis T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Stem Cell Proliferation Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining DN2 Thymocyte Differentiation Positive Regulation Of Chromosome Organization	Protein Transport Intracellular Transport
Pathways		2-LTR circle formation Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)	Delirium ( 29631748) Lung adenocarcinoma ( 31326317) Metabolite levels ( 23823483)
Interacting Genes		103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATOSA ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	11 interacting genes: AP1G1 AP1G2 CLTC GGA1 GGA2 GGA3 LIG4 MAP1LC3B PEX14 STAT5B UBE3A
Entrez ID		3981	54812
HPRD ID		03500	10635
Ensembl ID		ENSG00000174405	ENSG00000119844
Uniprot IDs		A0A0C4DGV9 A8K8Q4 P49917	A0A8Q3SI61 A0A8Q3SIA4 A0A8Q3WKU6 A0A8Q3WM48 Q53GW0 Q6ULP2
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG 7D9K 7D9Y 7LSY 7LT3 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB
Enriched GO Terms of Interacting Partners?		Histone H2AXS139 Kinase Activity Respiratory Electron Transport Chain Electron Transport Chain Aerobic Respiration Aerobic Electron Transport Chain Cellular Respiration Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining ATP Synthesis Coupled Electron Transport Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Repair Generation Of Precursor Metabolites And Energy Macromolecule Metabolic Process V(D)J Recombination Proton Transmembrane Transport Respiratory Chain Complex I DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Protein Localization To Site Of Double-strand Break Energy Derivation By Oxidation Of Organic Compounds Extracellular Exosome Response To Ionizing Radiation DNA Metabolic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Telomere Maintenance Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cytochrome-c Oxidase Activity Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Chromosome Organization Chromosome Organization Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Proton Motive Force-driven ATP Synthesis ATP Metabolic Process NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Response To Radiation DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Positive Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process RNA Binding NADH Dehydrogenase (ubiquinone) Activity Regulation Of Cellular Response To Heat DNA Recombination	Post-Golgi Vesicle-mediated Transport Intracellular Protein Transport Trans-Golgi Network Golgi Vesicle Transport Protein Localization To Cell Surface Protein Transport Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Cellular Localization Establishment Of Localization In Cell Clathrin-coated Vesicle Small GTPase Binding Endosome Membrane AP-1 Adaptor Complex Intracellular Protein Localization Ubiquitin Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Endosome Golgi To Vacuole Transport Cytosolic Transport Intracellular Vesicle Vesicle-mediated Transport To The Plasma Membrane Protein-containing Complex Disassembly Vacuolar Transport Membrane Coat Cytoplasmic Vesicle Membrane Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Localization To Plasma Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Early Endosome Membrane Establishment Of Protein Localization To Membrane T Cell Differentiation In Thymus Protein Localization To Cell Periphery Regulation Of Natural Killer Cell Mediated Cytotoxicity Endosomal Transport Regulation Of Natural Killer Cell Mediated Immunity Establishment Of Integrated Proviral Latency Peroxisome Transport Along Microtubule Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Leukocyte Mediated Cytotoxicity Golgi Apparatus Positive Regulation Of Cell Killing Protein Localization To Membrane Clathrin-coated Pit
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