LIG4 and NDUFA13

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		LIG4	NDUFA13
Gene Name		ligase IV, DNA, ATP-dependent	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Mitochondrial Respiratory Chain Complex I Integral Component Of Membrane Mitochondrial Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding	NADH Dehydrogenase Activity Protein Binding ATP Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Ligation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion DNA Biosynthetic Process Establishment Of Integrated Proviral Latency	Positive Regulation Of Peptidase Activity Respiratory Electron Transport Chain Negative Regulation Of Cell Growth Cellular Response To Interferon-beta Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Metabolic Process Small Molecule Metabolic Process Protein Import Into Mitochondrial Inner Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Retinoic Acid Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		103 interactors: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 CAP1 CCDC176 CLU COL1A2 COMMD1 COX1 COX2 COX3 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C ND1 ND4 ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	5 interactors: EXOSC6 LIG4 STAT3 UBE3A XRN1
Entrez ID		3981	51079
HPRD ID		03500	09452
Ensembl ID		ENSG00000174405
Uniprot IDs		P49917	Q9P0J0
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization DNA Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress Metabolic Process Cell Cycle Process Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Response To Stress Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Mitochondrial Electron Transport, NADH To Ubiquinone Mitotic Cell Cycle Checkpoint Positive Regulation Of Signal Transduction By P53 Class Mediator Viral Process Response To Radiation Mitotic Cell Cycle Process Protein Metabolic Process Negative Regulation Of Cell Cycle Response To Gamma Radiation Posttranscriptional Regulation Of Gene Expression Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Translation Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Electron Transport Chain Regulation Of Protein Ubiquitination Regulation Of Response To DNA Damage Stimulus Cell Cycle V(D)J Recombination Pro-B Cell Differentiation Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Ubiquitin-protein Transferase Activity	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immunoglobulin Production Somatic Stem Cell Maintenance Viral Process Sperm Entry DNA Ligation Involved In DNA Recombination RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Stem Cell Maintenance Leukocyte Activation Involved In Immune Response B Cell Activation MRNA Catabolic Process Cellular Macromolecule Catabolic Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity RNA Catabolic Process Central Nervous System Development Intracellular Receptor Signaling Pathway DNA Recombination Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Stem Cell Development Lagging Strand Elongation Pro-B Cell Differentiation Leukocyte Mediated Immunity Adaptive Immune Response Nuclear MRNA Surveillance RNA Metabolic Process Establishment Of Integrated Proviral Latency Stem Cell Differentiation DNA Deamination Negative Regulation Of Glycolytic Process RNA Surveillance Immunoglobulin V(D)J Recombination Radial Glial Cell Differentiation Establishment Of Viral Latency Histone MRNA Catabolic Process T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair RRNA Catabolic Process Lymphoid Progenitor Cell Differentiation Lymphocyte Activation DNA Ligation Interleukin-6-mediated Signaling Pathway
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Difference) ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Intersection) ?