LIG4 and KIF3A

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		LIG4	KIF3A
Description		DNA ligase 4	kinesin family member 3A
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Kinesin II Complex Cell Projection Extracellular Exosome Ciliary Tip Axon Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding AMP Binding Ligase Activity Metal Ion Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Protein Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Protein Phosphatase Binding Spectrin Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Ionizing Radiation Response To Gamma Radiation Neurogenesis T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Stem Cell Proliferation Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining DN2 Thymocyte Differentiation Positive Regulation Of Chromosome Organization	Organelle Organization Microtubule-based Movement Anterograde Axonal Transport Centriole-centriole Cohesion Transport Along Microtubule Protein Transport Cell Projection Organization Microtubule Anchoring At Centrosome Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Cell Junction
Pathways		2-LTR circle formation Nonhomologous End-Joining (NHEJ)	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 22197932 23042114 25574825 26482879) Atopic march ( 26542096) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Refractive error ( 32231278)
Interacting Genes		103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATOSA ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	21 interacting genes: APP BTG3 DISC1 DSCAM DSCR9 GRB2 HUNK KIF3B KIF3C LIG4 MAP3K10 MAP3K11 MORC3 NEK1 NRIP1 PLEKHA5 PPP1R15A RPGR TRIM14 TULP3 VHL
Entrez ID		3981	11127
HPRD ID		03500	05250
Ensembl ID		ENSG00000174405	ENSG00000131437
Uniprot IDs		A0A0C4DGV9 A8K8Q4 P49917	B4DHG8 E9PES4 J3KPF9 Q05CT3 Q9Y496
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG 7D9K 7D9Y 7LSY 7LT3 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB
Enriched GO Terms of Interacting Partners?		Histone H2AXS139 Kinase Activity Respiratory Electron Transport Chain Electron Transport Chain Aerobic Respiration Aerobic Electron Transport Chain Cellular Respiration Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining ATP Synthesis Coupled Electron Transport Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Repair Generation Of Precursor Metabolites And Energy Macromolecule Metabolic Process V(D)J Recombination Proton Transmembrane Transport Respiratory Chain Complex I DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Protein Localization To Site Of Double-strand Break Energy Derivation By Oxidation Of Organic Compounds Extracellular Exosome Response To Ionizing Radiation DNA Metabolic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Telomere Maintenance Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cytochrome-c Oxidase Activity Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Chromosome Organization Chromosome Organization Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Proton Motive Force-driven ATP Synthesis ATP Metabolic Process NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Response To Radiation DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Positive Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process RNA Binding NADH Dehydrogenase (ubiquinone) Activity Regulation Of Cellular Response To Heat DNA Recombination	Cilium Kinesin Complex JUN Kinase Kinase Kinase Activity Centrosome Positive Regulation Of JUN Kinase Activity Amyloid-beta Complex Positive Regulation Of Metabolic Process Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Plasma Membrane Bounded Cell Projection Organization Central Nervous System Development Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Transport Along Microtubule Amylin Binding Positive Regulation Of JNK Cascade Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Amyloid Fibril Formation Microtubule-based Process Protein Serine/threonine Kinase Binding Cytoplasm Microtubule-based Movement Positive Regulation Of Axon Extension Guanyl-nucleotide Exchange Factor Adaptor Activity ATP Binding Microtubule Establishment Of Integrated Proviral Latency Positive Regulation Of MAP Kinase Activity Phosphorylation Peptidyl-serine Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Cilium Assembly Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Cilium Organization Ciliary Base Ovarian Follicle Rupture Neuron Recognition Ciliary Tip Molecular Adaptor Activity Intraciliary Transport Cell Projection Organization Cytoskeleton-dependent Intracellular Transport Acetylcholine Receptor Activator Activity PTB Domain Binding
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