LIG4 and EIF4A1

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		LIG4	EIF4A1
Gene Name		ligase IV, DNA, ATP-dependent	eukaryotic translation initiation factor 4A1
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Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding	RNA Cap Binding Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Ligation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion DNA Biosynthetic Process Establishment Of Integrated Proviral Latency	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Organ Regeneration Cellular Protein Metabolic Process
Pathways		HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle	Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		103 interactors: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 CAP1 CCDC176 CLU COL1A2 COMMD1 COX1 COX2 COX3 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C ND1 ND4 ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	10 interactors: EIF4G1 EIF4G2 EIF4G3 LIG4 LPPR4 MAPK6 PAIP1 PRMT1 UCHL5 UPF2
Entrez ID		3981	1973
HPRD ID		03500	04030
Ensembl ID		ENSG00000174405	ENSG00000161960
Uniprot IDs		P49917	P60842
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP	2G9N 2ZU6 3EIQ
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization DNA Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress Metabolic Process Cell Cycle Process Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Response To Stress Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Mitochondrial Electron Transport, NADH To Ubiquinone Mitotic Cell Cycle Checkpoint Positive Regulation Of Signal Transduction By P53 Class Mediator Viral Process Response To Radiation Mitotic Cell Cycle Process Protein Metabolic Process Negative Regulation Of Cell Cycle Response To Gamma Radiation Posttranscriptional Regulation Of Gene Expression Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Translation Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Electron Transport Chain Regulation Of Protein Ubiquitination Regulation Of Response To DNA Damage Stimulus Cell Cycle V(D)J Recombination Pro-B Cell Differentiation Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Ubiquitin-protein Transferase Activity	Translational Initiation Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Translation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Metabolic Process Cellular Macromolecule Catabolic Process DNA Ligation Involved In DNA Recombination Cellular Protein Metabolic Process MRNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process RNA 3'-end Processing Regulation Of Protein Metabolic Process Gene Expression MRNA Metabolic Process Viral Process Cellular Macromolecule Biosynthetic Process Cellular Response To Cytokine Stimulus Macromolecule Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Protein Metabolic Process Lagging Strand Elongation Pro-B Cell Differentiation Response To Cytokine Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Establishment Of Integrated Proviral Latency Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Immunoglobulin V(D)J Recombination Establishment Of Viral Latency DNA Recombination T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Metabolic Process Catabolic Process Lymphoid Progenitor Cell Differentiation Peptidyl-arginine N-methylation Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Histone H4-R3 Methylation RNA Metabolic Process DNA Ligation Cellular Response To Stimulus
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?