LIG4 and UBB

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		LIG4	UBB
Description		DNA ligase 4	ubiquitin B
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Membrane Endocytic Vesicle Membrane Vesicle Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding AMP Binding Ligase Activity Metal Ion Binding	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Ionizing Radiation Response To Gamma Radiation Neurogenesis T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Stem Cell Proliferation Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining DN2 Thymocyte Differentiation Positive Regulation Of Chromosome Organization	Male Meiosis I Female Meiosis I Male Gonad Development Female Gonad Development Protein Ubiquitination Modification-dependent Protein Catabolic Process Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Positive Regulation Of Protein Ubiquitination Regulation Of Neuron Apoptotic Process Mitochondrion Transport Along Microtubule Neuron Projection Morphogenesis Regulation Of Mitochondrial Membrane Potential Adipose Tissue Development Fat Pad Development Regulation Of Proteasomal Protein Catabolic Process Seminiferous Tubule Development Energy Homeostasis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Monoubiquitination
Pathways		2-LTR circle formation Nonhomologous End-Joining (NHEJ)	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling VLDLR internalisation and degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Interferon alpha/beta signaling Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Signaling by CSF1 (M-CSF) in myeloid cells Maturation of protein E SARS-CoV-1 activates/modulates innate immune responses Maturation of protein E Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Negative regulation of FLT3 FLT3 signaling by CBL mutants Regulation of BACH1 activity Signaling by ALK fusions and activated point mutants TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation KEAP1-NFE2L2 pathway Regulation of NF-kappa B signaling GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Amyloid fiber formation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Regulation of pyruvate metabolism GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			(4s)-5-Fluoro-L-Leucine
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321)
Interacting Genes		103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATOSA ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	81 interacting genes: APP ATXN3 BIRC2 BRAP BRCA1 CDC25A CDC34 CDIP1 CDKN1B CDT1 CDX2 CHEK1 DAZAP2 DESI1 DNMT1 DUSP1 ECT2 EGFR ELF4 EPS15 ERBB2 FAM168A FANCD2 FSHR HDAC6 HGS HLA-A IKBKB IKBKG JUN LIG4 LYN MAPT MDM2 MTURN MYBL2 MYC NR3C1 NTRK1 NTRK2 OPTN PCNA PIN1 PLEKHB2 PLSCR4 POLI PRKN PSMD4 RABGEF1 RAD23A RAD23B RNF11 SDCBP SH3KBP1 SKP2 SMAD4 SMURF1 SNCA SNCAIP SQSTM1 STUB1 SYK TAX1BP1 TGFBR1 TP53 TRAF6 TRIM37 TRIM5 UBASH3A UBASH3B UBE2N UBE2S UBQLN1 UBQLN2 UCHL1 UIMC1 USP1 USP30 WEE2-AS1 WWOX XIAP
Entrez ID		3981	7314
HPRD ID		03500	06771
Ensembl ID		ENSG00000174405	ENSG00000170315
Uniprot IDs		A0A0C4DGV9 A8K8Q4 P49917	P0CG47 Q5U5U6
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG 7D9K 7D9Y 7LSY 7LT3 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB	2KHW 2MBB 2MRO 2MSG 2N13 4UEL 4UF6 4WHV 4WLR 4WUR 4XOF 4ZFR 4ZFT 4ZPZ 4ZUX 5BNB 5CAW 5CRA 5CVM 5CVN 5CVO 5D0K 5D0M 5DFL 5DK8 5E6J 5EDV 5EMZ 5EYA 5GJQ 5GO7 5GO8 5GOB 5GOC 5GOD 5GOG 5GOH 5GOI 5GOJ 5GOK 5H7S 5IBK 5IFR 5JBY 5JG6 5JP3 5JTJ 5JTV 5K9P 5KGF 5KHY 5KYC 5KYD 5KYE 5KYF 5L8H 5L8W 5L9T 5LN1 5LRV 5LRW 5LRX 5M93 5MNJ 5N2W 5N38 5NL5 5NLJ 5NVG 5O44 5O6T 5OHK 5OHL 5OHN 5OHP 5TOF 5TOG 5TUT 5TXK 5UJL 5UJN 5ULF 5ULH 5ULK 5V1Y 5V1Z 5VEY 5VF0 5VNZ 5VO0 5VZM 5VZW 5W46 5WFI 5X3M 5X3N 5X3O 5XBO 5XDP 5XK4 5XK5 5XPK 5YDR 5YIJ 5YIK 5YMY 5YT6 5ZBU 5ZD0 6ASR 6BVA 6BYH 6C16 6CP2 6DGF 6EI1 6FDK 6FGE 6FTX 6FX4 6FYH 6GLC 6GZS 6H4H 6HEI 6HEK 6IF1 6ISU 6JB6 6JB7 6JMA 6K4I 6K9P 6KOW 6KOX 6LP2 6MSB 6MSD 6MSE 6MSG 6N13 6NJ9 6NJG 6O96 6OAM 6PGV 6PZV 6QF8 6QK9 6QML 6TBM 6UH5 6XAA 6XQC 6XZ1 7AY2 7BBD 7BU0 7CAP 7DNI 7DNJ 7E8I 7F7X 7JMS 7LYC 7M2K 7MC9 7MEY 7MYF 7MYH 7NBB 7NPO 7OJE 7OJX 7QO4 7QO5 7RBR 7RMA 7UD5 7US1 7UV5 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 7W3U 7W54 7XCR 7XCT 7YQK 8A67 8BS9 8C07 8C61 8CMR 8DMQ 8DMS 8DU4 8EFW 8EFX 8EHO 8G6G 8G6H 8G6Q 8G6S 8GRM 8H1T 8HQY 8IC9 8ITP 8J1P 8K0G 8OYP 8PP6 8Q00 8RQI 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8T2D 8TXV 8TXW 8TXX 8V25 8V26 8V27 8V28 8W31 8WG5 8XEP 9AVT 9AVW 9AZJ 9B0Z 9B12 9C5E 9EMK 9HNW
Enriched GO Terms of Interacting Partners?		Histone H2AXS139 Kinase Activity Respiratory Electron Transport Chain Electron Transport Chain Aerobic Respiration Aerobic Electron Transport Chain Cellular Respiration Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining ATP Synthesis Coupled Electron Transport Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Repair Generation Of Precursor Metabolites And Energy Macromolecule Metabolic Process V(D)J Recombination Proton Transmembrane Transport Respiratory Chain Complex I DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Protein Localization To Site Of Double-strand Break Energy Derivation By Oxidation Of Organic Compounds Extracellular Exosome Response To Ionizing Radiation DNA Metabolic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Telomere Maintenance Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cytochrome-c Oxidase Activity Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Chromosome Organization Chromosome Organization Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Proton Motive Force-driven ATP Synthesis ATP Metabolic Process NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Response To Radiation DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Positive Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process RNA Binding NADH Dehydrogenase (ubiquinone) Activity Regulation Of Cellular Response To Heat DNA Recombination	Positive Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Response To Stress Negative Regulation Of Signal Transduction Identical Protein Binding Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification Process Protein Polyubiquitination Regulation Of Cellular Response To Stress Post-translational Protein Modification Protein-containing Complex Regulation Of Apoptotic Process Nucleus Ubiquitin-dependent Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Modification-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Programmed Cell Death Enzyme Binding Positive Regulation Of Intracellular Signal Transduction DNA Damage Response Positive Regulation Of Signaling Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Ubiquitin Binding Cytosol Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Ubiquitin-protein Transferase Activity Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Negative Regulation Of Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Nucleoplasm
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