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LIG4 and COL1A2
Number of citations of the paper that reports this interaction (PubMedID
22990118
)
93
Data Source:
BioGRID
(two hybrid)
LIG4
COL1A2
Description
DNA ligase 4
collagen type I alpha 2 chain
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Nonhomologous End Joining Complex
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type I Trimer
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Extracellular Exosome
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
AMP Binding
Ligase Activity
Metal Ion Binding
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Protein-macromolecule Adaptor Activity
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Repair
Base-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Ionizing Radiation
Response To Gamma Radiation
Neurogenesis
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Stem Cell Proliferation
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
DN2 Thymocyte Differentiation
Positive Regulation Of Chromosome Organization
Skeletal System Development
Blood Vessel Development
Transforming Growth Factor Beta Receptor Signaling Pathway
Rho Protein Signal Transduction
Regulation Of Blood Pressure
Collagen Fibril Organization
Bone Mineralization
Collagen Metabolic Process
Odontogenesis
Skin Morphogenesis
Animal Organ Development
Protein Heterotrimerization
Cellular Response To Amino Acid Stimulus
Extracellular Matrix Assembly
Pathways
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Interleukin-4 and Interleukin-13 signaling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
Collagen chain trimerization
Enhanced cleavage of VWF variant by ADAMTS13
Enhanced binding of GP1BA variant to VWF multimer:collagen
Defective VWF cleavage by ADAMTS13 variant
Defective VWF binding to collagen type I
Defective binding of VWF variant to GPIb:IX:V
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Osteogenesis imperfecta
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Aging (
22773346
)
Appendicular lean mass (
33097823
)
Heel bone mineral density (
30598549
)
Immune reponse to smallpox (secreted IL-12p40) (
22610502
)
Intelligence (
22449649
)
Low bone mineral density (hip) (
26235824
)
Low bone mineral density (spine) (
26235824
)
Mean forced vital capacity from 2 exams (
17903307
)
Post bronchodilator FEV1 (
26634245
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Interacting Genes
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATOSA
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
31 interacting genes:
APP
BGN
CD36
CD44
CD93
COL5A3
DCN
EIF3F
FN1
ITGA2
ITGA2B
ITGB3
KCNIP4
LIG4
LUM
MESD
MMP9
MYOC
P4HB
PDGFA
PDGFB
SERPINB5
SGTA
SGTB
SHBG
SMARCD1
SPARC
TGFBI
UBQLN1
UBQLN2
VWF
Entrez ID
3981
1278
HPRD ID
03500
00363
Ensembl ID
ENSG00000174405
ENSG00000164692
Uniprot IDs
A0A0C4DGV9
A8K8Q4
P49917
A0A0S2Z3H5
P08123
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
7D9K
7D9Y
7LSY
7LT3
7NFC
7NFE
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
5CTD
5CTI
5CVA
6JEC
Enriched GO Terms of Interacting Partners
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Histone H2AXS139 Kinase Activity
Respiratory Electron Transport Chain
Electron Transport Chain
Aerobic Respiration
Aerobic Electron Transport Chain
Cellular Respiration
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
ATP Synthesis Coupled Electron Transport
Positive Regulation Of Signal Transduction By P53 Class Mediator
DNA Repair
Generation Of Precursor Metabolites And Energy
Macromolecule Metabolic Process
V(D)J Recombination
Proton Transmembrane Transport
Respiratory Chain Complex I
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair
Immunoglobulin V(D)J Recombination
Nonhomologous End Joining Complex
Protein Localization To Site Of Double-strand Break
Energy Derivation By Oxidation Of Organic Compounds
Extracellular Exosome
Response To Ionizing Radiation
DNA Metabolic Process
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Double-strand Break Repair
Telomere Maintenance
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Cytochrome-c Oxidase Activity
Proton Motive Force-driven Mitochondrial ATP Synthesis
Positive Regulation Of Chromosome Organization
Chromosome Organization
Protein Localization To Chromosome
Positive Regulation Of DNA Metabolic Process
Proton Motive Force-driven ATP Synthesis
ATP Metabolic Process
NADH Dehydrogenase Complex Assembly
Mitochondrial Respiratory Chain Complex I Assembly
Response To Radiation
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Repair
Positive Regulation Of Telomere Maintenance
Regulation Of Protein Metabolic Process
RNA Binding
NADH Dehydrogenase (ubiquinone) Activity
Regulation Of Cellular Response To Heat
DNA Recombination
Collagen Binding
Extracellular Matrix Binding
Platelet Alpha Granule Lumen
Positive Regulation Of Cell Migration
Extracellular Matrix
Extracellular Matrix Structural Constituent
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Integrin Binding
Cell Surface
Cell-substrate Adhesion
Extracellular Region
Platelet Alpha Granule Membrane
Golgi Lumen
Cell-matrix Adhesion
Positive Regulation Of Fibroblast Proliferation
Regulation Of Cell Migration
Extracellular Space
Identical Protein Binding
Regulation Of Cell Motility
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Locomotion
Cell Adhesion
Positive Regulation Of Cell Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Fibroblast Proliferation
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Cell Adhesion
Regulation Of Glomerular Mesangial Cell Proliferation
Positive Regulation Of ERK1 And ERK2 Cascade
Angiogenesis
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Platelet-derived Growth Factor Receptor Binding
Regulation Of Cell-substrate Adhesion
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
TRC Complex
Positive Regulation Of ERAD Pathway
Platelet Alpha Granule
Positive Regulation Of Cell Communication
Positive Regulation Of Leukocyte Migration
Regulation Of Cellular Component Organization
Regulation Of Smooth Muscle Cell Migration
Integrin AlphaIIb-beta3 Complex
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Regulation Of Body Fluid Levels
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