UNC119 and FXYD6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UNC119	FXYD6
Description		unc-119 lipid binding chaperone	FXYD domain containing ion transport regulator 6
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Intercellular Bridge Synapse Spindle Midzone	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Lipid Binding	Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity
	Biological Process	Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Protein Transport Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS			Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)
Interacting Genes		104 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CFTR CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24	67 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35E1 SLC35E3 SLC35H1 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119
Entrez ID		9094	53826
HPRD ID		04927	09456
Ensembl ID		ENSG00000109103	ENSG00000137726
Uniprot IDs		K7EN86 Q13432	Q9H0Q3
PDB IDs		3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A 7UMO 9GKG	8D3U 8D3V 8D3W 8D3X 8D3Y
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Glutamatergic Synapse Leukocyte Migration Positive Regulation Of Cell Activation Cytosol Enzyme Binding Positive Regulation Of Cell-cell Adhesion Protein Binding T Cell Receptor Binding RAGE Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Cell Development Regulation Of Calcium Ion Import Across Plasma Membrane Cytoplasm Nucleus T Cell Activation Positive Regulation Of Monoatomic Ion Transmembrane Transport Gamma-delta T Cell Receptor Complex Lymphocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Calcium-dependent Protein Binding Regulation Of T Cell Activation Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Developmental Process T Cell Costimulation Positive Regulation Of Leukocyte Differentiation T Cell Receptor Complex Intracellular Signaling Cassette CD8 Receptor Binding Nucleotide Binding Gamma-delta T Cell Activation Negative Regulation Of Cell Development Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phagocytosis Regulation Of Leukocyte Proliferation Response To Gamma Radiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Schaffer Collateral - CA1 Synapse	Membrane Transmembrane Transport Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Antiporter Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Monoatomic Ion Transport Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid
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