UNC119 and RGL2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UNC119	RGL2
Description		unc-119 lipid binding chaperone	ral guanine nucleotide dissociation stimulator like 2
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Intercellular Bridge Synapse Spindle Midzone	Cytosol
	Molecular Function	Protein Binding Lipid Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Protein Transport Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Ral Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways			RAF/MAP kinase cascade
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		104 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CFTR CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24	19 interacting genes: ADAMTSL4 CCDC90B CRMP1 CYSRT1 EEF1G GORASP2 HRAS KAT5 KAT7 KPNA2 KPRP KRAS KRTAP10-8 NOTCH2NLA NRAS RAC1 RALA RAP1B UNC119
Entrez ID		9094	5863
HPRD ID		04927	03810
Ensembl ID		ENSG00000109103	ENSG00000237441
Uniprot IDs		K7EN86 Q13432	A0A024RCS9 O15211
PDB IDs		3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A 7UMO 9GKG	8AU4 8B69
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Glutamatergic Synapse Leukocyte Migration Positive Regulation Of Cell Activation Cytosol Enzyme Binding Positive Regulation Of Cell-cell Adhesion Protein Binding T Cell Receptor Binding RAGE Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Cell Development Regulation Of Calcium Ion Import Across Plasma Membrane Cytoplasm Nucleus T Cell Activation Positive Regulation Of Monoatomic Ion Transmembrane Transport Gamma-delta T Cell Receptor Complex Lymphocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Calcium-dependent Protein Binding Regulation Of T Cell Activation Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Developmental Process T Cell Costimulation Positive Regulation Of Leukocyte Differentiation T Cell Receptor Complex Intracellular Signaling Cassette CD8 Receptor Binding Nucleotide Binding Gamma-delta T Cell Activation Negative Regulation Of Cell Development Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phagocytosis Regulation Of Leukocyte Proliferation Response To Gamma Radiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Schaffer Collateral - CA1 Synapse	G Protein Activity GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Ras Protein Signal Transduction Intracellular Signaling Cassette Regulation Of Neuronal Synaptic Plasticity Histone H4K16 Acetyltransferase Activity Intracellular Signal Transduction Histone H4 Acetyltransferase Activity Developmental Process Peptidyl-lysine Acetylation Positive Regulation Of Ruffle Assembly Cell Development Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Rac Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Signal Transduction Golgi Membrane Regulation Of Ruffle Assembly Protein-containing Complex Binding Negative Regulation Of Receptor-mediated Endocytosis Histone Acetyltransferase Activity Protein Acetylation Protein-membrane Adaptor Activity Endoplasmic Reticulum Membrane Establishment Of Skin Barrier Homeostasis Of Number Of Cells Within A Tissue Semaphorin-plexin Signaling Pathway Regulation Of Postsynapse Assembly Histone H2AK5 Acetyltransferase Activity Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Pigment Cell Development Skin Epidermis Development Hydrolase Activity Response To Radiation Endocytosis Regulation Of Cell Projection Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Cellular Developmental Process GTPase Complex Cellular Senescence Modulation Of Chemical Synaptic Transmission MAPK Cascade Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
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